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Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study

INTRODUCTION: Achieving a goal of serum urate levels in patients with gout is an important way to prevent gout and its complications while it remains difficult with a low targeting rate worldwidely. Currently, hyperuricemia classification has not been widely applied to the management of gout owing t...

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Autores principales: Xue, Xiaomei, Yuan, Xuan, Han, Lin, Li, Xinde, Merriman, Tony R., Cui, Lingling, Liu, Zhen, Sun, Wenyan, Wang, Can, Yan, Fei, He, Yuwei, Ji, Aichang, Lu, Jie, Li, Changgui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801777/
https://www.ncbi.nlm.nih.gov/pubmed/35111784
http://dx.doi.org/10.3389/fmed.2021.806710
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author Xue, Xiaomei
Yuan, Xuan
Han, Lin
Li, Xinde
Merriman, Tony R.
Cui, Lingling
Liu, Zhen
Sun, Wenyan
Wang, Can
Yan, Fei
He, Yuwei
Ji, Aichang
Lu, Jie
Li, Changgui
author_facet Xue, Xiaomei
Yuan, Xuan
Han, Lin
Li, Xinde
Merriman, Tony R.
Cui, Lingling
Liu, Zhen
Sun, Wenyan
Wang, Can
Yan, Fei
He, Yuwei
Ji, Aichang
Lu, Jie
Li, Changgui
author_sort Xue, Xiaomei
collection PubMed
description INTRODUCTION: Achieving a goal of serum urate levels in patients with gout is an important way to prevent gout and its complications while it remains difficult with a low targeting rate worldwidely. Currently, hyperuricemia classification has not been widely applied to the management of gout owing to insufficient clinical evidences. This study aimed to evaluate the effectiveness of achieving target urate based on hyperuricemia classification in Chinese patients with gout. METHODS: In this prospective study, patients with gout receiving urate lowering therapy with benzbromarone were assigned to two groups, a renal underexcretion and an unclassified type. The primary endpoint was the proportion of patients achieving the serum urate target (<360 μmol/L) during the 12-week study. The frequency of acute gout attacks as well as physical and chemical indicators were secondary endpoints. RESULTS: Target serum urate level was achieved in 60.5% of underexcretors compared with 39.0% of patients of the unclassified type at week 12 (P = 0.002). Blood glucose and cholesterol levels were lower in the underexcretor group compared with the unclassified type group at the end of the trial, without significant different frequencies in gout flare during the study. In subgroup analysis, stratified by body mass index and estimated glomerular filtration rate, the proportion of patients with serum urate <360 μmol/L was greater in the underexcretion compared with the unclassified type group. CONCLUSIONS: The increased achievement of target serum urate in the underexcretion group supports the use of a clinical hyperuricemia typing treatment strategy for gout.
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spelling pubmed-88017772022-02-01 Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study Xue, Xiaomei Yuan, Xuan Han, Lin Li, Xinde Merriman, Tony R. Cui, Lingling Liu, Zhen Sun, Wenyan Wang, Can Yan, Fei He, Yuwei Ji, Aichang Lu, Jie Li, Changgui Front Med (Lausanne) Medicine INTRODUCTION: Achieving a goal of serum urate levels in patients with gout is an important way to prevent gout and its complications while it remains difficult with a low targeting rate worldwidely. Currently, hyperuricemia classification has not been widely applied to the management of gout owing to insufficient clinical evidences. This study aimed to evaluate the effectiveness of achieving target urate based on hyperuricemia classification in Chinese patients with gout. METHODS: In this prospective study, patients with gout receiving urate lowering therapy with benzbromarone were assigned to two groups, a renal underexcretion and an unclassified type. The primary endpoint was the proportion of patients achieving the serum urate target (<360 μmol/L) during the 12-week study. The frequency of acute gout attacks as well as physical and chemical indicators were secondary endpoints. RESULTS: Target serum urate level was achieved in 60.5% of underexcretors compared with 39.0% of patients of the unclassified type at week 12 (P = 0.002). Blood glucose and cholesterol levels were lower in the underexcretor group compared with the unclassified type group at the end of the trial, without significant different frequencies in gout flare during the study. In subgroup analysis, stratified by body mass index and estimated glomerular filtration rate, the proportion of patients with serum urate <360 μmol/L was greater in the underexcretion compared with the unclassified type group. CONCLUSIONS: The increased achievement of target serum urate in the underexcretion group supports the use of a clinical hyperuricemia typing treatment strategy for gout. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8801777/ /pubmed/35111784 http://dx.doi.org/10.3389/fmed.2021.806710 Text en Copyright © 2022 Xue, Yuan, Han, Li, Merriman, Cui, Liu, Sun, Wang, Yan, He, Ji, Lu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xue, Xiaomei
Yuan, Xuan
Han, Lin
Li, Xinde
Merriman, Tony R.
Cui, Lingling
Liu, Zhen
Sun, Wenyan
Wang, Can
Yan, Fei
He, Yuwei
Ji, Aichang
Lu, Jie
Li, Changgui
Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title_full Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title_fullStr Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title_full_unstemmed Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title_short Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study
title_sort effect of clinical typing on serum urate targets of benzbromarone in chinese gout patients: a prospective cohort study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801777/
https://www.ncbi.nlm.nih.gov/pubmed/35111784
http://dx.doi.org/10.3389/fmed.2021.806710
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