Cargando…

Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo

Overexpression of the multidrug resistance (MDR)-related protein P-glycoprotein (PGP1), which actively extrudes chemotherapeutic agents from cells and significantly decreases the efficacy of chemotherapy, is viewed as a major obstacle in osteosarcoma chemotherapy. Anlotinib, a novel tyrosine kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Gangyang, Cao, Lingling, Jiang, Yafei, Zhang, Tao, Wang, Hongsheng, Wang, Zhuoying, Xu, Jing, Mao, Min, Hua, Yingqi, Cai, Zhengdong, Ma, Xiaojun, Hu, Shuo, Zhou, Chenghao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801797/ https://www.ncbi.nlm.nih.gov/pubmed/35111065 http://dx.doi.org/10.3389/fphar.2021.798837

Ejemplares similares

Correlation between Patient‐Derived Xenograft Modeling and Prognosis in Osteosarcoma
por: Sun, Mengxiong, et al.
Publicado: (2022)

Long non-coding RNAs in osteosarcoma
por: Chen, Ruiling, et al.
Publicado: (2017)

Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A
por: Wang, Zhuoying, et al.
Publicado: (2019)

CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma
por: Wang, Zongyi, et al.
Publicado: (2019)

NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
por: Wang, Hongsheng, et al.
Publicado: (2017)

Non-Nutritive Sweeteners Acesulfame Potassium and Sucralose Are Competitive Inhibitors of the Human P-glycoprotein/Multidrug Resistance Protein 1 (PGP/MDR1)
por: Danner, Laura, et al.
Publicado: (2023)

Corrigendum: NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
por: Wang, Hongsheng, et al.
Publicado: (2017)

Antitumor activity of Raddeanin A is mediated by Jun amino‐terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma
por: Wang, Zhuoying, et al.
Publicado: (2019)

Drug resistance‐related microRNAs in osteosarcoma: Translating basic evidence into therapeutic strategies
por: Chen, Ruiling, et al.
Publicado: (2019)

Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
por: Zheng, Ying, et al.
Publicado: (2018)

Identification of a novel glycolysis-related gene signature for predicting the prognosis of osteosarcoma patients
por: Yang, Mengkai, et al.
Publicado: (2021)

Bromodomain Inhibition Attenuates the Progression and Sensitizes the Chemosensitivity of Osteosarcoma by Repressing GP130/STAT3 Signaling
por: Jiang, Yafei, et al.
Publicado: (2021)

CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis
por: Wang, Zhuoying, et al.
Publicado: (2016)

Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925
por: Yang, X, et al.
Publicado: (2014)

MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma
por: Yang, Mengkai, et al.
Publicado: (2021)

Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment
por: Jiang, Yafei, et al.
Publicado: (2022)

Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation
por: Yafei, Jiang, et al.
Publicado: (2021)

Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019)
por: Xu, Jing, et al.
Publicado: (2019)

Tocilizumab (monoclonal anti-IL-6R antibody) reverses anlotinib resistance in osteosarcoma
por: Xu, Jiuhui, et al.
Publicado: (2023)

A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)-mediated multidrug resistance
por: Zahra, Rida, et al.
Publicado: (2020)

Shikonin promotes adriamycin-induced apoptosis by upregulating caspase-3 and caspase-8 in osteosarcoma
por: Yang, Qing, et al.
Publicado: (2017)

Interaction potential of Carmegliptin with P-glycoprotein (Pgp) transporter in healthy volunteers
por: Kuhlmann, Olaf, et al.
Publicado: (2014)

HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein
por: Chen, Jianfang, et al.
Publicado: (2014)

Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity
por: Wang, Hongsheng, et al.
Publicado: (2022)

Hematoporphyrin Monomethyl Ether-Mediated Photodynamic Therapy Selectively Kills Sarcomas by Inducing Apoptosis
por: Zeng, Hui, et al.
Publicado: (2013)

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
por: Cianfriglia, Maurizio, et al.
Publicado: (2007)

Immunogenic cell death in cancer therapy: Present and emerging inducers
por: Zhou, Jingyi, et al.
Publicado: (2019)

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport
por: Evers, R, et al.
Publicado: (2000)

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis
por: Fu, Zeze, et al.
Publicado: (2013)

Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteosarcoma cells and upregulates the expression of AKT
por: CHEN, QUANCHI, et al.
Publicado: (2015)

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †
por: Teodori, Elisabetta, et al.
Publicado: (2020)

N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD
por: O'Reilly, Philip, et al.
Publicado: (2009)

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents
por: Feng, Senling, et al.
Publicado: (2020)

Effects of Myristicin in Association with Chemotherapies on the Reversal of the Multidrug Resistance (MDR) Mechanism in Cancer
por: Seneme, Elisa Frederico, et al.
Publicado: (2022)

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
por: Braconi, Laura, et al.
Publicado: (2022)

Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation
por: Xu, Jing, et al.
Publicado: (2019)

Down Regulation of CIAPIN1 Reverses Multidrug Resistance in Human Breast Cancer Cells by Inhibiting MDR1
por: Lu, Dan, et al.
Publicado: (2012)

Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model
por: Takeshita, H, et al.
Publicado: (2000)

PGP: Pretty Good Privacy
por: Garfinkel, Simson
Publicado: (1995)

A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide.
por: Philip, P. A., et al.
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_ql2uo54vlahgg8vdtimt6t6m6b