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Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling

In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration. Prior work showed sickling was reduced by 5-hydroxylmethyl-2-furfural (5-HMF), which stabi...

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Detalles Bibliográficos
Autores principales:	Chow, Pak Hin, Cox, Charles D., Pei, Jinxin V., Anabaraonye, Nancy, Nourmohammadi, Saeed, Henderson, Sam W., Martinac, Boris, Abdulmalik, Osheiza, Yool, Andrea J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801817/ https://www.ncbi.nlm.nih.gov/pubmed/35111062 http://dx.doi.org/10.3389/fphar.2021.794791

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