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Prefoldin Function in Cellular Protein Homeostasis and Human Diseases
Cellular functions are largely performed by proteins. Defects in the production, folding, or removal of proteins from the cell lead to perturbations in cellular functions that can result in pathological conditions for the organism. In cells, molecular chaperones are part of a network of surveillance...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801880/ https://www.ncbi.nlm.nih.gov/pubmed/35111762 http://dx.doi.org/10.3389/fcell.2021.816214 |
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author | Tahmaz, Ismail Shahmoradi Ghahe, Somayeh Topf, Ulrike |
author_facet | Tahmaz, Ismail Shahmoradi Ghahe, Somayeh Topf, Ulrike |
author_sort | Tahmaz, Ismail |
collection | PubMed |
description | Cellular functions are largely performed by proteins. Defects in the production, folding, or removal of proteins from the cell lead to perturbations in cellular functions that can result in pathological conditions for the organism. In cells, molecular chaperones are part of a network of surveillance mechanisms that maintains a functional proteome. Chaperones are involved in the folding of newly synthesized polypeptides and assist in refolding misfolded proteins and guiding proteins for degradation. The present review focuses on the molecular co-chaperone prefoldin. Its canonical function in eukaryotes involves the transfer of newly synthesized polypeptides of cytoskeletal proteins to the tailless complex polypeptide 1 ring complex (TRiC/CCT) chaperonin which assists folding of the polypeptide chain in an energy-dependent manner. The canonical function of prefoldin is well established, but recent research suggests its broader function in the maintenance of protein homeostasis under physiological and pathological conditions. Interestingly, non-canonical functions were identified for the prefoldin complex and also for its individual subunits. We discuss the latest findings on the prefoldin complex and its subunits in the regulation of transcription and proteasome-dependent protein degradation and its role in neurological diseases, cancer, viral infections and rare anomalies. |
format | Online Article Text |
id | pubmed-8801880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88018802022-02-01 Prefoldin Function in Cellular Protein Homeostasis and Human Diseases Tahmaz, Ismail Shahmoradi Ghahe, Somayeh Topf, Ulrike Front Cell Dev Biol Cell and Developmental Biology Cellular functions are largely performed by proteins. Defects in the production, folding, or removal of proteins from the cell lead to perturbations in cellular functions that can result in pathological conditions for the organism. In cells, molecular chaperones are part of a network of surveillance mechanisms that maintains a functional proteome. Chaperones are involved in the folding of newly synthesized polypeptides and assist in refolding misfolded proteins and guiding proteins for degradation. The present review focuses on the molecular co-chaperone prefoldin. Its canonical function in eukaryotes involves the transfer of newly synthesized polypeptides of cytoskeletal proteins to the tailless complex polypeptide 1 ring complex (TRiC/CCT) chaperonin which assists folding of the polypeptide chain in an energy-dependent manner. The canonical function of prefoldin is well established, but recent research suggests its broader function in the maintenance of protein homeostasis under physiological and pathological conditions. Interestingly, non-canonical functions were identified for the prefoldin complex and also for its individual subunits. We discuss the latest findings on the prefoldin complex and its subunits in the regulation of transcription and proteasome-dependent protein degradation and its role in neurological diseases, cancer, viral infections and rare anomalies. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8801880/ /pubmed/35111762 http://dx.doi.org/10.3389/fcell.2021.816214 Text en Copyright © 2022 Tahmaz, Shahmoradi Ghahe and Topf. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Tahmaz, Ismail Shahmoradi Ghahe, Somayeh Topf, Ulrike Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title | Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title_full | Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title_fullStr | Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title_full_unstemmed | Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title_short | Prefoldin Function in Cellular Protein Homeostasis and Human Diseases |
title_sort | prefoldin function in cellular protein homeostasis and human diseases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801880/ https://www.ncbi.nlm.nih.gov/pubmed/35111762 http://dx.doi.org/10.3389/fcell.2021.816214 |
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