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Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination
Many human birth defects and neurodevelopmental disorders are caused by loss-of-function mutations in a single copy of transcription factor (TF) and chromatin regulator genes. Although this dosage sensitivity has long been known, how and why haploinsufficiency (HI) of transcriptional regulators lead...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Company of Biologists Ltd
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801891/ https://www.ncbi.nlm.nih.gov/pubmed/35089335 http://dx.doi.org/10.1242/bio.058896 |