Cargando…

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on several diseases. Here, we investigated whether h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruan, Weibin, Ji, Xinyun, Qin, Yating, Zhang, Xinxin, Wan, Xiaoning, Zhu, Chuanmeng, Lv, Chao, Hu, Chongqing, Zhou, Juan, Lu, Li, Guo, Xiaomei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801946/ https://www.ncbi.nlm.nih.gov/pubmed/35111758 http://dx.doi.org/10.3389/fcell.2021.792257

Ejemplares similares

Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy
por: Qin, Yating, et al.
Publicado: (2021)

Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities
por: Zhang, Xinxin, et al.
Publicado: (2021)

Harmine Inhibits Multiple TLR-Induced Inflammatory Expression through Modulation of NF-κB p65, JNK, and STAT1
por: Jin, So-Jung, et al.
Publicado: (2022)

Harmine Alleviates Titanium Particle-Induced Inflammatory Bone Destruction by Immunomodulatory Effect on the Macrophage Polarization and Subsequent Osteogenic Differentiation
por: Wang, Liangliang, et al.
Publicado: (2021)

Protective Effect of Qiliqiangxin against Doxorubicin-Induced Cardiomyopathy by Suppressing Excessive Autophagy and Apoptosis
por: Qin, Yating, et al.
Publicado: (2022)

Bioactive compound C498-0670 alleviates LPS-induced sepsis via JAK/STAT and NFκB signaling pathways
por: Xu, Jing, et al.
Publicado: (2023)

Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer
por: Ruan, Shu, et al.
Publicado: (2017)

Combination of Niclosamide and Pirfenidone Alleviates Pulmonary Fibrosis by Inhibiting Oxidative Stress and MAPK/Nf-κB and STATs Regulated Genes
por: Wanas, Hanaa, et al.
Publicado: (2023)

Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways
por: Moqbel, Safwat Adel Abdo, et al.
Publicado: (2020)

4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression
por: Chang, Chien-Hsin, et al.
Publicado: (2018)

Xanthatin Alleviates LPS-Induced Inflammatory Response in RAW264.7 Macrophages by Inhibiting NF-κB, MAPK and STATs Activation
por: Liu, Yuanqi, et al.
Publicado: (2022)

Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway
por: Zhang, Xinxin, et al.
Publicado: (2020)

A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling
por: Zhang, Xinxin, et al.
Publicado: (2021)

Maresin 1 Mitigates Sepsis-Associated Acute Kidney Injury in Mice via Inhibition of the NF-κB/STAT3/MAPK Pathways
por: Sun, ShuJun, et al.
Publicado: (2019)

Angiotensin-(1–7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways
por: Chen, Xin-Sen, et al.
Publicado: (2023)

Alkaloids from Aconitum carmichaelii Alleviates DSS-Induced Ulcerative Colitis in Mice via MAPK/NF-κB/STAT3 Signaling Inhibition
por: Huang, Chuanqi, et al.
Publicado: (2022)

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
por: Ji, Jiaojiao, et al.
Publicado: (2019)

Novel harmine derivatives for tumor targeted therapy
por: Li, Siwen, et al.
Publicado: (2015)

Harmine stimulates proliferation of human neural progenitors
por: Dakic, Vanja, et al.
Publicado: (2016)

Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling
por: Xia, Min, et al.
Publicado: (2022)

CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway
por: Shen, Yanan, et al.
Publicado: (2021)

Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-κB Signaling Pathway
por: Sun, Minqiong, et al.
Publicado: (2021)

Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment
por: Qi, Tongbing, et al.
Publicado: (2022)

Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway
por: Zhang, Xinxin, et al.
Publicado: (2023)

Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation
por: Pagano, Bruno, et al.
Publicado: (2017)

Harmine Acts as an Indirect Inhibitor of Intracellular Protein Aggregation
por: Jain, Swati, et al.
Publicado: (2020)

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages
por: Fang, Hua, et al.
Publicado: (2021)

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway
por: Fu, Yuanyuan, et al.
Publicado: (2021)

STAT3 Regulates miR-384 Transcription During Th17 Polarization
por: Han, Jingjing, et al.
Publicado: (2019)

Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-κB Activation
por: Zhuang, Yuanyuan, et al.
Publicado: (2017)

(-)-α-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-κB Signaling in Mast Cell
por: Li, Guangxia, et al.
Publicado: (2022)

Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells
por: Chen, Minhao, et al.
Publicado: (2021)

Dapagliflozin Alleviates Coxsackievirus B3-induced Acute Viral Myocarditis by Regulating the Macrophage Polarization Through Stat3-related Pathways
por: Yan, Pengcheng, et al.
Publicado: (2022)

Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
por: Réus, Gislaine Z., et al.
Publicado: (2010)

Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice
por: Salahshoor, Mohammad Reza, et al.
Publicado: (2019)

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance
por: Machado, Susana, et al.
Publicado: (2020)

Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices
por: Abdelazim, Ahmed H., et al.
Publicado: (2023)

Sesquiterpene lactones-enriched fractions from Xanthium mongolicum Kitag alleviate RA by regulating M1 macrophage polarization via NF-κB and MAPK signaling pathway
por: Han, Jing, et al.
Publicado: (2023)

Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways
por: Chen, Yan, et al.
Publicado: (2018)

Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
por: Li, Baixing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sj5qcl96jc116bbk878ns655gs