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Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response

Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans. Using human pluripotent stem cells (hPSCs), we established a Dox-ind...

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Detalles Bibliográficos
Autores principales:	Qi, Yan, Ye, Yida, Wang, Ruxiang, Yu, Senlin, Zhang, Yue, Lv, Jing, Jin, Wenwen, Xia, Shutao, Jiang, Wei, Li, Yifei, Zhang, Donghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802056/ https://www.ncbi.nlm.nih.gov/pubmed/35091324 http://dx.doi.org/10.1016/j.redox.2022.102248

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