Navigating a complex landscape – A review of the relationship between inflammation and childhood trauma and the potential roles in the expression of symptoms of depression

Recent research has explored associations between depression and inflammation, and interactions between childhood trauma and both factors. Major Depressive Disorder (MDD) is a prevalent issue and with one third of patients not responding to standard antidepressant treatments, it is crucial to develop our understanding. While research delves into the complex landscape of the roles of both childhood trauma and inflammation in depression, it is customary for literature to explore effects on presence of depression. However, understanding if childhood trauma and inflammation may be affecting the symptom profiles of depression and what implications this may have, is lacking.