Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice

OBJECTIVE: Inducible nitric oxide (NO) synthase (NOS2) is a well-documented inflammatory mediator of insulin resistance in obesity. NOS2 expression is induced in both adipocytes and macrophages within adipose tissue during high-fat (HF)-induced obesity. METHODS: Eight-week-old male mice with adipocy...

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Detalles Bibliográficos
Autores principales: Vilela, Vanessa Rodrigues, Samson, Nolwenn, Nachbar, Renato, Perazza, Lia Rossi, Lachance, Gabriel, Rokatoarivelo, Volatiana, Centano-Baez, Carolina, Zancan, Patricia, Sola-Penna, Mauro, Bellmann, Kerstin, Di Marzo, Vincenzo, Laplante, Mathieu, Marette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802131/
https://www.ncbi.nlm.nih.gov/pubmed/35033724
http://dx.doi.org/10.1016/j.molmet.2022.101437

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