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Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802142/ https://www.ncbi.nlm.nih.gov/pubmed/35115806 http://dx.doi.org/10.2147/JIR.S349572 |
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author | Pang, Qi-Ming Chen, Si-Yu Fu, Sheng-Ping Zhou, Hui Zhang, Qian Ao, Jun Luo, Xiao-Ping Zhang, Tao |
author_facet | Pang, Qi-Ming Chen, Si-Yu Fu, Sheng-Ping Zhou, Hui Zhang, Qian Ao, Jun Luo, Xiao-Ping Zhang, Tao |
author_sort | Pang, Qi-Ming |
collection | PubMed |
description | Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main contributor and directly influences neurological function recovery. In recent years, increasing evidence has shown that mesenchymal stem cells (MSCs) transplantation is a promising immunomodulatory strategy. Transplanted MSCs can regulate macrophage-, astrocyte-, and T lymphocyte-mediated neuroinflammation and help create a microenvironment that facilitates tissue repair and regeneration. This review focuses on the effects of different types of immune cells and MSCs, specifically the immunoregulatory capacity of MSCs in SCI and repair. We will also discuss how to exploit MSCs transplantation to regulate immune cells and develop novel therapeutic strategies for SCI. |
format | Online Article Text |
id | pubmed-8802142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-88021422022-02-02 Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury Pang, Qi-Ming Chen, Si-Yu Fu, Sheng-Ping Zhou, Hui Zhang, Qian Ao, Jun Luo, Xiao-Ping Zhang, Tao J Inflamm Res Review Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main contributor and directly influences neurological function recovery. In recent years, increasing evidence has shown that mesenchymal stem cells (MSCs) transplantation is a promising immunomodulatory strategy. Transplanted MSCs can regulate macrophage-, astrocyte-, and T lymphocyte-mediated neuroinflammation and help create a microenvironment that facilitates tissue repair and regeneration. This review focuses on the effects of different types of immune cells and MSCs, specifically the immunoregulatory capacity of MSCs in SCI and repair. We will also discuss how to exploit MSCs transplantation to regulate immune cells and develop novel therapeutic strategies for SCI. Dove 2022-01-26 /pmc/articles/PMC8802142/ /pubmed/35115806 http://dx.doi.org/10.2147/JIR.S349572 Text en © 2022 Pang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Pang, Qi-Ming Chen, Si-Yu Fu, Sheng-Ping Zhou, Hui Zhang, Qian Ao, Jun Luo, Xiao-Ping Zhang, Tao Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title | Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title_full | Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title_fullStr | Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title_full_unstemmed | Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title_short | Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury |
title_sort | regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802142/ https://www.ncbi.nlm.nih.gov/pubmed/35115806 http://dx.doi.org/10.2147/JIR.S349572 |
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