Cargando…

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main co...

Descripción completa

Detalles Bibliográficos
Autores principales: Pang, Qi-Ming, Chen, Si-Yu, Fu, Sheng-Ping, Zhou, Hui, Zhang, Qian, Ao, Jun, Luo, Xiao-Ping, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802142/
https://www.ncbi.nlm.nih.gov/pubmed/35115806
http://dx.doi.org/10.2147/JIR.S349572
_version_ 1784642614208757760
author Pang, Qi-Ming
Chen, Si-Yu
Fu, Sheng-Ping
Zhou, Hui
Zhang, Qian
Ao, Jun
Luo, Xiao-Ping
Zhang, Tao
author_facet Pang, Qi-Ming
Chen, Si-Yu
Fu, Sheng-Ping
Zhou, Hui
Zhang, Qian
Ao, Jun
Luo, Xiao-Ping
Zhang, Tao
author_sort Pang, Qi-Ming
collection PubMed
description Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main contributor and directly influences neurological function recovery. In recent years, increasing evidence has shown that mesenchymal stem cells (MSCs) transplantation is a promising immunomodulatory strategy. Transplanted MSCs can regulate macrophage-, astrocyte-, and T lymphocyte-mediated neuroinflammation and help create a microenvironment that facilitates tissue repair and regeneration. This review focuses on the effects of different types of immune cells and MSCs, specifically the immunoregulatory capacity of MSCs in SCI and repair. We will also discuss how to exploit MSCs transplantation to regulate immune cells and develop novel therapeutic strategies for SCI.
format Online
Article
Text
id pubmed-8802142
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-88021422022-02-02 Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury Pang, Qi-Ming Chen, Si-Yu Fu, Sheng-Ping Zhou, Hui Zhang, Qian Ao, Jun Luo, Xiao-Ping Zhang, Tao J Inflamm Res Review Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main contributor and directly influences neurological function recovery. In recent years, increasing evidence has shown that mesenchymal stem cells (MSCs) transplantation is a promising immunomodulatory strategy. Transplanted MSCs can regulate macrophage-, astrocyte-, and T lymphocyte-mediated neuroinflammation and help create a microenvironment that facilitates tissue repair and regeneration. This review focuses on the effects of different types of immune cells and MSCs, specifically the immunoregulatory capacity of MSCs in SCI and repair. We will also discuss how to exploit MSCs transplantation to regulate immune cells and develop novel therapeutic strategies for SCI. Dove 2022-01-26 /pmc/articles/PMC8802142/ /pubmed/35115806 http://dx.doi.org/10.2147/JIR.S349572 Text en © 2022 Pang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Pang, Qi-Ming
Chen, Si-Yu
Fu, Sheng-Ping
Zhou, Hui
Zhang, Qian
Ao, Jun
Luo, Xiao-Ping
Zhang, Tao
Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title_full Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title_fullStr Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title_full_unstemmed Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title_short Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
title_sort regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802142/
https://www.ncbi.nlm.nih.gov/pubmed/35115806
http://dx.doi.org/10.2147/JIR.S349572
work_keys_str_mv AT pangqiming regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT chensiyu regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT fushengping regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT zhouhui regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT zhangqian regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT aojun regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT luoxiaoping regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury
AT zhangtao regulatoryroleofmesenchymalstemcellsonsecondaryinflammationinspinalcordinjury