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Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation

Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble fact...

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Autores principales: Pan, Yongli, Wang, Ting, Zhao, Zhiqiang, Wei, Wei, Yang, Xinyu, Wang, Xianbin, Xin, Wenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802408/
https://www.ncbi.nlm.nih.gov/pubmed/35115805
http://dx.doi.org/10.2147/JIR.S338162
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author Pan, Yongli
Wang, Ting
Zhao, Zhiqiang
Wei, Wei
Yang, Xinyu
Wang, Xianbin
Xin, Wenqiang
author_facet Pan, Yongli
Wang, Ting
Zhao, Zhiqiang
Wei, Wei
Yang, Xinyu
Wang, Xianbin
Xin, Wenqiang
author_sort Pan, Yongli
collection PubMed
description Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble factors and cells due to various stimuli including tissue injury. Although there is no doubt that inflammation is critically involved in multiple biological and pathological processes alike, the precise mechanisms being involved are still open for debate. In this context, the role of Neat1 as a regulator of inflammation, microglial activation, and lipid accumulation under various inflammatory conditions remains elusive. Herein, we review the regulation of Neat1 and how it modulates the expression of its target genes. Thereafter, we will review the impact of Neat1 on inflammation by activating or inhibiting various signaling pathways, such as microRNAs, AKT, TLR4, TRAF6, and NF-κB.
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spelling pubmed-88024082022-02-02 Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation Pan, Yongli Wang, Ting Zhao, Zhiqiang Wei, Wei Yang, Xinyu Wang, Xianbin Xin, Wenqiang J Inflamm Res Review Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble factors and cells due to various stimuli including tissue injury. Although there is no doubt that inflammation is critically involved in multiple biological and pathological processes alike, the precise mechanisms being involved are still open for debate. In this context, the role of Neat1 as a regulator of inflammation, microglial activation, and lipid accumulation under various inflammatory conditions remains elusive. Herein, we review the regulation of Neat1 and how it modulates the expression of its target genes. Thereafter, we will review the impact of Neat1 on inflammation by activating or inhibiting various signaling pathways, such as microRNAs, AKT, TLR4, TRAF6, and NF-κB. Dove 2022-01-26 /pmc/articles/PMC8802408/ /pubmed/35115805 http://dx.doi.org/10.2147/JIR.S338162 Text en © 2022 Pan et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Pan, Yongli
Wang, Ting
Zhao, Zhiqiang
Wei, Wei
Yang, Xinyu
Wang, Xianbin
Xin, Wenqiang
Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title_full Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title_fullStr Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title_full_unstemmed Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title_short Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
title_sort novel insights into the emerging role of neat1 and its effects downstream in the regulation of inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802408/
https://www.ncbi.nlm.nih.gov/pubmed/35115805
http://dx.doi.org/10.2147/JIR.S338162
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