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Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review

BACKGROUND: Expanding technologies of early detection of Alzheimer’s disease allow to identify individuals at risk of dementia in early and asymptomatic disease stages. Neuropsychiatric symptoms, such as anxiety and depression, are common in the course of AD and may be clinically observed many years...

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Autores principales: Rostamzadeh, Ayda, Kahlert, Anna, Kalthegener, Franziska, Jessen, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802419/
https://www.ncbi.nlm.nih.gov/pubmed/35101105
http://dx.doi.org/10.1186/s13195-021-00956-8
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author Rostamzadeh, Ayda
Kahlert, Anna
Kalthegener, Franziska
Jessen, Frank
author_facet Rostamzadeh, Ayda
Kahlert, Anna
Kalthegener, Franziska
Jessen, Frank
author_sort Rostamzadeh, Ayda
collection PubMed
description BACKGROUND: Expanding technologies of early detection of Alzheimer’s disease allow to identify individuals at risk of dementia in early and asymptomatic disease stages. Neuropsychiatric symptoms, such as anxiety and depression, are common in the course of AD and may be clinically observed many years before the onset of significant cognitive symptoms. To date, therapeutic interventions for AD focus on pharmacological and life style modification-based strategies. However, despite good evidence for psychotherapy in late-life depression, evidence for such therapeutic approaches to improve cognitive and emotional well-being and thereby reduce psychological risk factors in the course of AD are sparse. METHODS: A systematic review was conducted in PUBMED, PsycINFO, Web of Science, and Clinical Trials to summarize the state of evidence on psychotherapeutic and psychoeducational interventions for individuals at risk for Alzheimer’s dementia. Eligible articles needed to apply a manualized and standardized psychotherapeutic or psychoeducational content administered by trained professionals for individuals with subjective cognitive decline or mild cognitive impairment and measure mental health, quality of life or well-being. RESULTS: The literature search yielded 32 studies that were included in this narrative summary. The data illustrates heterogeneous therapeutic approaches with mostly small sample sizes and short follow-up monitoring. Strength of evidence from randomized-controlled studies for interventions that may improve mood and well-being is scarce. Qualitative data suggests positive impact on cognitive restructuring, and disease acceptance, including positive effects on quality of life. Specific therapeutic determinants of efficacy have not been identified to date. CONCLUSIONS: This review underlines the need of specific psychotherapeutic and psychoeducational approaches for individuals at risk of Alzheimer’s dementia, particularly in terms of an early intervention aiming at improving mental health and well-being. One challenge is the modification of psychotherapeutic techniques according to the different stages of cognitive decline in the course of AD, which is needed to be sensitive to the individual needs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00956-8.
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spelling pubmed-88024192022-02-02 Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review Rostamzadeh, Ayda Kahlert, Anna Kalthegener, Franziska Jessen, Frank Alzheimers Res Ther Review BACKGROUND: Expanding technologies of early detection of Alzheimer’s disease allow to identify individuals at risk of dementia in early and asymptomatic disease stages. Neuropsychiatric symptoms, such as anxiety and depression, are common in the course of AD and may be clinically observed many years before the onset of significant cognitive symptoms. To date, therapeutic interventions for AD focus on pharmacological and life style modification-based strategies. However, despite good evidence for psychotherapy in late-life depression, evidence for such therapeutic approaches to improve cognitive and emotional well-being and thereby reduce psychological risk factors in the course of AD are sparse. METHODS: A systematic review was conducted in PUBMED, PsycINFO, Web of Science, and Clinical Trials to summarize the state of evidence on psychotherapeutic and psychoeducational interventions for individuals at risk for Alzheimer’s dementia. Eligible articles needed to apply a manualized and standardized psychotherapeutic or psychoeducational content administered by trained professionals for individuals with subjective cognitive decline or mild cognitive impairment and measure mental health, quality of life or well-being. RESULTS: The literature search yielded 32 studies that were included in this narrative summary. The data illustrates heterogeneous therapeutic approaches with mostly small sample sizes and short follow-up monitoring. Strength of evidence from randomized-controlled studies for interventions that may improve mood and well-being is scarce. Qualitative data suggests positive impact on cognitive restructuring, and disease acceptance, including positive effects on quality of life. Specific therapeutic determinants of efficacy have not been identified to date. CONCLUSIONS: This review underlines the need of specific psychotherapeutic and psychoeducational approaches for individuals at risk of Alzheimer’s dementia, particularly in terms of an early intervention aiming at improving mental health and well-being. One challenge is the modification of psychotherapeutic techniques according to the different stages of cognitive decline in the course of AD, which is needed to be sensitive to the individual needs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00956-8. BioMed Central 2022-01-31 /pmc/articles/PMC8802419/ /pubmed/35101105 http://dx.doi.org/10.1186/s13195-021-00956-8 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Rostamzadeh, Ayda
Kahlert, Anna
Kalthegener, Franziska
Jessen, Frank
Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title_full Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title_fullStr Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title_full_unstemmed Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title_short Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
title_sort psychotherapeutic interventions in individuals at risk for alzheimer’s dementia: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802419/
https://www.ncbi.nlm.nih.gov/pubmed/35101105
http://dx.doi.org/10.1186/s13195-021-00956-8
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