TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

BACKGROUND: Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion leads to the development of preeclampsia (PE) which is a leading cause of maternal and perinatal mortality a...

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Detalles Bibliográficos
Autores principales: Fang, Lanlan, Yan, Yang, Gao, Yibo, Wu, Ze, Wang, Zhen, Yang, Sizhu, Cheng, Jung-Chien, Sun, Ying-Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802482/
https://www.ncbi.nlm.nih.gov/pubmed/35101033
http://dx.doi.org/10.1186/s12958-022-00902-9

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