Role of the S100 protein family in rheumatoid arthritis

Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction of joints and surrounding tissues eventually causes joint deformities and dysfunction or eve...

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Autores principales: Wu, Yuan-yuan, Li, Xiao-feng, Wu, Sha, Niu, Xue-ni, Yin, Su-qin, Huang, Cheng, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802512/
https://www.ncbi.nlm.nih.gov/pubmed/35101111
http://dx.doi.org/10.1186/s13075-022-02727-8
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author Wu, Yuan-yuan
Li, Xiao-feng
Wu, Sha
Niu, Xue-ni
Yin, Su-qin
Huang, Cheng
Li, Jun
author_facet Wu, Yuan-yuan
Li, Xiao-feng
Wu, Sha
Niu, Xue-ni
Yin, Su-qin
Huang, Cheng
Li, Jun
author_sort Wu, Yuan-yuan
collection PubMed
description Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction of joints and surrounding tissues eventually causes joint deformities and dysfunction or even loss. The S100 protein family is one of the biggest subtribes in the calcium-binding protein family and has more than 20 members. The overexpression of most S100 proteins in rheumatoid arthritis is closely related to its pathogenesis. This paper reviews the relationship between S100 proteins and the occurrence and development of rheumatoid arthritis. It will provide insights into the development of new clinical diagnostic markers and therapeutic targets for rheumatoid arthritis.
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spelling pubmed-88025122022-02-02 Role of the S100 protein family in rheumatoid arthritis Wu, Yuan-yuan Li, Xiao-feng Wu, Sha Niu, Xue-ni Yin, Su-qin Huang, Cheng Li, Jun Arthritis Res Ther Review Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction of joints and surrounding tissues eventually causes joint deformities and dysfunction or even loss. The S100 protein family is one of the biggest subtribes in the calcium-binding protein family and has more than 20 members. The overexpression of most S100 proteins in rheumatoid arthritis is closely related to its pathogenesis. This paper reviews the relationship between S100 proteins and the occurrence and development of rheumatoid arthritis. It will provide insights into the development of new clinical diagnostic markers and therapeutic targets for rheumatoid arthritis. BioMed Central 2022-01-31 2022 /pmc/articles/PMC8802512/ /pubmed/35101111 http://dx.doi.org/10.1186/s13075-022-02727-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Yuan-yuan
Li, Xiao-feng
Wu, Sha
Niu, Xue-ni
Yin, Su-qin
Huang, Cheng
Li, Jun
Role of the S100 protein family in rheumatoid arthritis
title Role of the S100 protein family in rheumatoid arthritis
title_full Role of the S100 protein family in rheumatoid arthritis
title_fullStr Role of the S100 protein family in rheumatoid arthritis
title_full_unstemmed Role of the S100 protein family in rheumatoid arthritis
title_short Role of the S100 protein family in rheumatoid arthritis
title_sort role of the s100 protein family in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802512/
https://www.ncbi.nlm.nih.gov/pubmed/35101111
http://dx.doi.org/10.1186/s13075-022-02727-8
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