Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

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Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait. We hypothesized that these common gain-of-functi...

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Detalles Bibliográficos
Autores principales: Nln, Ilona, FERNANDEZ-RUIZ, RUTH, MUSKARDIN, THERESA L. WAMPLER, PAREDES, JACQUELINE L., BLAZER, ASHIRA D., TUMINELLO, STEPHANIE, ATTUR, MUKUNDAN, ITURRATE, EDUARDO, PETRILLI, CHRISTOPHER M., ABRAMSON, STEVEN B., CHAKRAVARTI, ARAVINDA, NIEWOLD, TIMOTHY B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802623/
https://www.ncbi.nlm.nih.gov/pubmed/35114420
http://dx.doi.org/10.1016/j.trsl.2022.01.007
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