Report of Two Cases of Acquired Idiopathic Haemophilia

Acquired haemophilia is a rare haemorrhagic dyscrasia caused by autoantibodies against coagulation factors, most commonly factor VIII (FVIII). Even though about half of the cases are classified as idiopathic, acquired haemophilia is more common in the elderly and/or in individuals diagnosed with other immunogenic conditions such as malignancies, autoimmune diseases, or during puerperium. It can be life-threatening, presenting more frequently with major bleeding. We report two cases of acquired haemophilia classified as idiopathic in middle-aged patients with no predisposing factors identified during the diagnostic approach: their disease’s progression and complications, choice of treatment, and why and when to change it.