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Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

DOT1-like (DOT1L) histone methyltransferase is essential for mammalian erythropoiesis. Loss of DOT1L in knockout (Dot1l-KO) mouse embryos resulted in lethal anemia at midgestational age. The only recognized molecular function of DOT1L is its methylation of histone H3 lysine 79 (H3K79). We generated...

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Detalles Bibliográficos
Autores principales:	Malcom, Carrie A., Ratri, Anamika, Piasecka-Srader, Joanna, Borosha, Shaon, Chakravarthi, V. Praveen, Alvarez, Nehemiah S., Vivian, Jay L., Fields, Timothy A., Karim Rumi, M.A., Fields, Patrick E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802720/ https://www.ncbi.nlm.nih.gov/pubmed/35111761 http://dx.doi.org/10.3389/fcell.2021.813503

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