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Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer
Colorectal cancer (CRC) is the third prevalent cancer worldwide, the morbidity and mortality of which have been increasing in recent years. As molecular targeting agents, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (McAbs) have significantly increased the progression-free surv...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802825/ https://www.ncbi.nlm.nih.gov/pubmed/35111681 http://dx.doi.org/10.3389/fonc.2021.801319 |
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author | Chu, Jinjin Fang, Xianzhu Sun, Zhonghou Gai, Linlin Dai, Wenqing Li, Haibo Yan, Xinyi Du, Jinke Zhang, Lili Zhao, Lu Xu, Donghua Yan, Shushan |
author_facet | Chu, Jinjin Fang, Xianzhu Sun, Zhonghou Gai, Linlin Dai, Wenqing Li, Haibo Yan, Xinyi Du, Jinke Zhang, Lili Zhao, Lu Xu, Donghua Yan, Shushan |
author_sort | Chu, Jinjin |
collection | PubMed |
description | Colorectal cancer (CRC) is the third prevalent cancer worldwide, the morbidity and mortality of which have been increasing in recent years. As molecular targeting agents, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (McAbs) have significantly increased the progression-free survival (PFS) and overall survival (OS) of metastatic CRC (mCRC) patients. Nevertheless, most patients are eventually resistant to anti-EGFR McAbs. With the intensive study of the mechanism of anti-EGFR drug resistance, a variety of biomarkers and pathways have been found to participate in CRC resistance to anti-EGFR therapy. More and more studies have implicated non-coding RNAs (ncRNAs) primarily including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are widely involved in tumorigenesis and tumor progression. They function as essential regulators controlling the expression and function of oncogenes. Increasing data have shown ncRNAs affect the resistance of molecular targeted drugs in CRC including anti-EGFR McAbs. In this paper, we have reviewed the advance in mechanisms of ncRNAs in regulating anti-EGFR McAbs therapy resistance in CRC. It provides insight into exploring ncRNAs as new molecular targets and prognostic markers for CRC. |
format | Online Article Text |
id | pubmed-8802825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88028252022-02-01 Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer Chu, Jinjin Fang, Xianzhu Sun, Zhonghou Gai, Linlin Dai, Wenqing Li, Haibo Yan, Xinyi Du, Jinke Zhang, Lili Zhao, Lu Xu, Donghua Yan, Shushan Front Oncol Oncology Colorectal cancer (CRC) is the third prevalent cancer worldwide, the morbidity and mortality of which have been increasing in recent years. As molecular targeting agents, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (McAbs) have significantly increased the progression-free survival (PFS) and overall survival (OS) of metastatic CRC (mCRC) patients. Nevertheless, most patients are eventually resistant to anti-EGFR McAbs. With the intensive study of the mechanism of anti-EGFR drug resistance, a variety of biomarkers and pathways have been found to participate in CRC resistance to anti-EGFR therapy. More and more studies have implicated non-coding RNAs (ncRNAs) primarily including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are widely involved in tumorigenesis and tumor progression. They function as essential regulators controlling the expression and function of oncogenes. Increasing data have shown ncRNAs affect the resistance of molecular targeted drugs in CRC including anti-EGFR McAbs. In this paper, we have reviewed the advance in mechanisms of ncRNAs in regulating anti-EGFR McAbs therapy resistance in CRC. It provides insight into exploring ncRNAs as new molecular targets and prognostic markers for CRC. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8802825/ /pubmed/35111681 http://dx.doi.org/10.3389/fonc.2021.801319 Text en Copyright © 2022 Chu, Fang, Sun, Gai, Dai, Li, Yan, Du, Zhang, Zhao, Xu and Yan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chu, Jinjin Fang, Xianzhu Sun, Zhonghou Gai, Linlin Dai, Wenqing Li, Haibo Yan, Xinyi Du, Jinke Zhang, Lili Zhao, Lu Xu, Donghua Yan, Shushan Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title | Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title_full | Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title_fullStr | Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title_full_unstemmed | Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title_short | Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer |
title_sort | non-coding rnas regulate the resistance to anti-egfr therapy in colorectal cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802825/ https://www.ncbi.nlm.nih.gov/pubmed/35111681 http://dx.doi.org/10.3389/fonc.2021.801319 |
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