Cargando…

Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging

OBJECTIVE: Measurement of a component within the reference value is a widely used parameter in Biomedical Science. This study highlights the value of morphometric changes in healthy individuals’ brainstem structure and their application in the detection and diagnosis of neurodegenerative disorders....

Descripción completa

Detalles Bibliográficos
Autores principales: Rajagopal, Kadavigere V., D'Souza, Antony S., Verma, Aparna, Mamatha, Hosapatna, Prasanna, Lokadolalu C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802845/
https://www.ncbi.nlm.nih.gov/pubmed/35140570
http://dx.doi.org/10.1016/j.jtumed.2021.06.012
_version_ 1784642757220892672
author Rajagopal, Kadavigere V.
D'Souza, Antony S.
Verma, Aparna
Mamatha, Hosapatna
Prasanna, Lokadolalu C.
author_facet Rajagopal, Kadavigere V.
D'Souza, Antony S.
Verma, Aparna
Mamatha, Hosapatna
Prasanna, Lokadolalu C.
author_sort Rajagopal, Kadavigere V.
collection PubMed
description OBJECTIVE: Measurement of a component within the reference value is a widely used parameter in Biomedical Science. This study highlights the value of morphometric changes in healthy individuals’ brainstem structure and their application in the detection and diagnosis of neurodegenerative disorders. METHODS: This retrospective study included magnetic resonance (MR) images of 50 healthy individuals without neurological diseases, 35 clinically diagnosed individuals with Parkinson's disease (PD), and 12 individuals with Progressive Supranuclear Palsy (PSP). Measurements of midbrain area, pons area, ratio of midbrain to pons area, superior profile of midbrain, thickness of substantia nigra (SN), cerebral crus width, interpeduncular distance, and concavity of the crus were analysed as per the standard protocol. RESULTS: Patients with PD had mean anteroposterior diameter of 1.11 ± 0.1 cm, which was more than the control group and PSP patients. Additionally, PSP patients showed the least midbrain and pons area of 1.06 ± 0.34 and 4.01 ± 1.2 sq.cm, respectively, compared to other groups. The ratio of midbrain to pons area was the least among PSP patients (0.21 ± 0.06 cm). Mean thickness of the right and left middle cerebellar peduncles (1.25 ± 0.19 and 1.24 ± 0.17 cm) was less in the PD group. The width of the SN gradually reduced in PD and more so in PSP patients. The convex superior profile of the midbrain was a consistent feature in all groups. CONCLUSION: This study highlights the value of morphometrics of the brainstem profile in differentiating neurodegenerative diseases among aged, healthy individuals when combined with their clinical data.
format Online
Article
Text
id pubmed-8802845
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taibah University
record_format MEDLINE/PubMed
spelling pubmed-88028452022-02-08 Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging Rajagopal, Kadavigere V. D'Souza, Antony S. Verma, Aparna Mamatha, Hosapatna Prasanna, Lokadolalu C. J Taibah Univ Med Sci Original Article OBJECTIVE: Measurement of a component within the reference value is a widely used parameter in Biomedical Science. This study highlights the value of morphometric changes in healthy individuals’ brainstem structure and their application in the detection and diagnosis of neurodegenerative disorders. METHODS: This retrospective study included magnetic resonance (MR) images of 50 healthy individuals without neurological diseases, 35 clinically diagnosed individuals with Parkinson's disease (PD), and 12 individuals with Progressive Supranuclear Palsy (PSP). Measurements of midbrain area, pons area, ratio of midbrain to pons area, superior profile of midbrain, thickness of substantia nigra (SN), cerebral crus width, interpeduncular distance, and concavity of the crus were analysed as per the standard protocol. RESULTS: Patients with PD had mean anteroposterior diameter of 1.11 ± 0.1 cm, which was more than the control group and PSP patients. Additionally, PSP patients showed the least midbrain and pons area of 1.06 ± 0.34 and 4.01 ± 1.2 sq.cm, respectively, compared to other groups. The ratio of midbrain to pons area was the least among PSP patients (0.21 ± 0.06 cm). Mean thickness of the right and left middle cerebellar peduncles (1.25 ± 0.19 and 1.24 ± 0.17 cm) was less in the PD group. The width of the SN gradually reduced in PD and more so in PSP patients. The convex superior profile of the midbrain was a consistent feature in all groups. CONCLUSION: This study highlights the value of morphometrics of the brainstem profile in differentiating neurodegenerative diseases among aged, healthy individuals when combined with their clinical data. Taibah University 2021-08-11 /pmc/articles/PMC8802845/ /pubmed/35140570 http://dx.doi.org/10.1016/j.jtumed.2021.06.012 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rajagopal, Kadavigere V.
D'Souza, Antony S.
Verma, Aparna
Mamatha, Hosapatna
Prasanna, Lokadolalu C.
Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title_full Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title_fullStr Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title_full_unstemmed Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title_short Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
title_sort comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802845/
https://www.ncbi.nlm.nih.gov/pubmed/35140570
http://dx.doi.org/10.1016/j.jtumed.2021.06.012
work_keys_str_mv AT rajagopalkadavigerev comparativemorphometricevaluationofthebrainsteminneurodegenerativediseaseswithhealthyindividualsusingmagneticresonanceimaging
AT dsouzaantonys comparativemorphometricevaluationofthebrainsteminneurodegenerativediseaseswithhealthyindividualsusingmagneticresonanceimaging
AT vermaaparna comparativemorphometricevaluationofthebrainsteminneurodegenerativediseaseswithhealthyindividualsusingmagneticresonanceimaging
AT mamathahosapatna comparativemorphometricevaluationofthebrainsteminneurodegenerativediseaseswithhealthyindividualsusingmagneticresonanceimaging
AT prasannalokadolaluc comparativemorphometricevaluationofthebrainsteminneurodegenerativediseaseswithhealthyindividualsusingmagneticresonanceimaging