Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was perform...

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Detalles Bibliográficos
Autores principales: Gao, Jian, Wu, Zhigui, Zhao, Mingxia, Zhang, Rui, Li, Manru, Sun, Dongdong, Cheng, Haibo, Qi, Xianjia, Shen, Yuxian, Xu, Qiang, Chen, Hongqi, Chen, Dijun, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802865/
https://www.ncbi.nlm.nih.gov/pubmed/35127377
http://dx.doi.org/10.1016/j.apsb.2021.08.006

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