A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia

PURPOSE: 1% topical 5-fluorouracil (5-FU) is a treatment for ocular surface squamous neoplasia (OSSN) due to its effectiveness, low cost, and tolerable side effect profile. To our knowledge there is no reported sight-threatening corneal complication of 1% 5-FU for the treatment of OSSN. OBSERVATIONS...

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Autores principales: Lin, Weijie Violet, Rand, Gabriel M., Miller, Michael L., Marr, Brian P., Suh, Leejee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802883/
https://www.ncbi.nlm.nih.gov/pubmed/35128150
http://dx.doi.org/10.1016/j.ajoc.2022.101265
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author Lin, Weijie Violet
Rand, Gabriel M.
Miller, Michael L.
Marr, Brian P.
Suh, Leejee H.
author_facet Lin, Weijie Violet
Rand, Gabriel M.
Miller, Michael L.
Marr, Brian P.
Suh, Leejee H.
author_sort Lin, Weijie Violet
collection PubMed
description PURPOSE: 1% topical 5-fluorouracil (5-FU) is a treatment for ocular surface squamous neoplasia (OSSN) due to its effectiveness, low cost, and tolerable side effect profile. To our knowledge there is no reported sight-threatening corneal complication of 1% 5-FU for the treatment of OSSN. OBSERVATIONS: We report a 78 year-old man with bilateral conjunctival intraepithelial neoplasia (CIN) who developed bilateral corneoscleral ulceration and corneal perforation of the left eye after 1% 5-FU topical treatment. CONCLUSIONS AND IMPORTANCE: Our case report describes serious potential complications of 1% 5-FU, reviews possible risk factors associated with poor outcomes, and discusses our treatment approach.
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spelling pubmed-88028832022-02-04 A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia Lin, Weijie Violet Rand, Gabriel M. Miller, Michael L. Marr, Brian P. Suh, Leejee H. Am J Ophthalmol Case Rep Case Report PURPOSE: 1% topical 5-fluorouracil (5-FU) is a treatment for ocular surface squamous neoplasia (OSSN) due to its effectiveness, low cost, and tolerable side effect profile. To our knowledge there is no reported sight-threatening corneal complication of 1% 5-FU for the treatment of OSSN. OBSERVATIONS: We report a 78 year-old man with bilateral conjunctival intraepithelial neoplasia (CIN) who developed bilateral corneoscleral ulceration and corneal perforation of the left eye after 1% 5-FU topical treatment. CONCLUSIONS AND IMPORTANCE: Our case report describes serious potential complications of 1% 5-FU, reviews possible risk factors associated with poor outcomes, and discusses our treatment approach. Elsevier 2022-01-20 /pmc/articles/PMC8802883/ /pubmed/35128150 http://dx.doi.org/10.1016/j.ajoc.2022.101265 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lin, Weijie Violet
Rand, Gabriel M.
Miller, Michael L.
Marr, Brian P.
Suh, Leejee H.
A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title_full A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title_fullStr A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title_full_unstemmed A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title_short A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
title_sort case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802883/
https://www.ncbi.nlm.nih.gov/pubmed/35128150
http://dx.doi.org/10.1016/j.ajoc.2022.101265
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