Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor

Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%–10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported....

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Autores principales: Si, Hongfei, Wang, Jie, He, Rui, Yu, Xiuwen, Li, Shan, Huang, Jing, Li, Jie, Tang, Xia, Song, Xiaojuan, Tu, Zhengchao, Zhang, Zhang, Ding, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802890/
https://www.ncbi.nlm.nih.gov/pubmed/35111683
http://dx.doi.org/10.3389/fonc.2021.807200
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author Si, Hongfei
Wang, Jie
He, Rui
Yu, Xiuwen
Li, Shan
Huang, Jing
Li, Jie
Tang, Xia
Song, Xiaojuan
Tu, Zhengchao
Zhang, Zhang
Ding, Ke
author_facet Si, Hongfei
Wang, Jie
He, Rui
Yu, Xiuwen
Li, Shan
Huang, Jing
Li, Jie
Tang, Xia
Song, Xiaojuan
Tu, Zhengchao
Zhang, Zhang
Ding, Ke
author_sort Si, Hongfei
collection PubMed
description Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%–10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported. We have identified U937 as the first human AML cell line expressing the JAK3(M511I) activated mutation and confirmed that JAK3 inhibitors sensitively suppress the proliferation of U937 AML cells.
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spelling pubmed-88028902022-02-01 Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor Si, Hongfei Wang, Jie He, Rui Yu, Xiuwen Li, Shan Huang, Jing Li, Jie Tang, Xia Song, Xiaojuan Tu, Zhengchao Zhang, Zhang Ding, Ke Front Oncol Oncology Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%–10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported. We have identified U937 as the first human AML cell line expressing the JAK3(M511I) activated mutation and confirmed that JAK3 inhibitors sensitively suppress the proliferation of U937 AML cells. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8802890/ /pubmed/35111683 http://dx.doi.org/10.3389/fonc.2021.807200 Text en Copyright © 2022 Si, Wang, He, Yu, Li, Huang, Li, Tang, Song, Tu, Zhang and Ding https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Si, Hongfei
Wang, Jie
He, Rui
Yu, Xiuwen
Li, Shan
Huang, Jing
Li, Jie
Tang, Xia
Song, Xiaojuan
Tu, Zhengchao
Zhang, Zhang
Ding, Ke
Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title_full Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title_fullStr Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title_full_unstemmed Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title_short Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor
title_sort identification of u937(jak3-m511i) acute myeloid leukemia cells as a sensitive model to jak3 inhibitor
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802890/
https://www.ncbi.nlm.nih.gov/pubmed/35111683
http://dx.doi.org/10.3389/fonc.2021.807200
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