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Identification of U937(JAK3-M511I) Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor

Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%–10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported....

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Detalles Bibliográficos
Autores principales:	Si, Hongfei, Wang, Jie, He, Rui, Yu, Xiuwen, Li, Shan, Huang, Jing, Li, Jie, Tang, Xia, Song, Xiaojuan, Tu, Zhengchao, Zhang, Zhang, Ding, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802890/ https://www.ncbi.nlm.nih.gov/pubmed/35111683 http://dx.doi.org/10.3389/fonc.2021.807200

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