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Disulfiram Enhances the Activity of Polymyxin B Against Klebsiella pneumoniae by Inhibiting Lipid A Modification

BACKGROUND: The use of antibiotic adjuvants is a complementary strategy to the development of new antibiotics. The essential role of the ArnA dehydrogenase domain (ArnA_DH) in the addition of 4-amino-L-arabinose (L-Ara4N) to lipid A makes it a potential target in polymyxin adjuvant design. PURPOSE:...

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Detalles Bibliográficos
Autores principales:	Huang, Wei, Zhang, Jinyong, Liu, Shiyi, Hu, Chunxia, Zhang, Min, Cheng, Shumin, Yu, Huijuan, Zheng, Manling, Wu, Jinsong, Lu, Yuemei, Zou, Quanming, Cui, Ruiqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802902/ https://www.ncbi.nlm.nih.gov/pubmed/35115797 http://dx.doi.org/10.2147/IDR.S342641

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