Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes

AIMS: Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy and disarray, and myocardial stiffness due to interstitial fibrosis, which result in impaired left ventricular filling and diastolic dysfunction. The latter manifests as exercise intolerance, angina, and dyspnoea....

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Detalles Bibliográficos
Autores principales: Ramachandra, Chrishan J A, Kp, Myu Mai Ja, Chua, Jasper, Hernandez-Resendiz, Sauri, Liehn, Elisa A, Knöll, Ralph, Gan, Li-Ming, Michaëlsson, Erik, Jonsson, Malin K B, Ryden-Markinhuhta, Katarina, Bhat, Ratan V, Fritsche-Danielson, Regina, Lin, Ying-Hsi, Sadayappan, Sakthivel, Tang, Hak Chiaw, Wong, Philip, Shim, Winston, Hausenloy, Derek J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803077/
https://www.ncbi.nlm.nih.gov/pubmed/33705529
http://dx.doi.org/10.1093/cvr/cvab077

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