Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs

The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17...

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Detalles Bibliográficos
Autores principales: Ronchini, Chiara, Gandini, Sara, Pasqualato, Sebastiano, Mazzarella, Luca, Facciotti, Federica, Mapelli, Marina, Frige’, Gianmaria, Passerini, Rita, Pase, Luca, Capizzi, Silvio, Mastrilli, Fabrizio, Orecchia, Roberto, Natoli, Gioacchino, Pelicci, Pier Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803178/
https://www.ncbi.nlm.nih.gov/pubmed/35100309
http://dx.doi.org/10.1371/journal.pone.0263014
Descripción
Sumario:The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.

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