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Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers
PURPOSE: The purpose of this study is to introduce half‐beam volumetric‐modulated arc therapy (HVMAT), an innovative treatment planning technique from our work, for reducing dose to the organs at risk (OAR) during adjuvant radiotherapy for gynecological cancers. METHODS AND MATERIALS: Seventy‐two tr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803303/ https://www.ncbi.nlm.nih.gov/pubmed/34783436 http://dx.doi.org/10.1002/acm2.13472 |
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author | Yu, Pei‐Chieh Wu, Ching‐Jung Nien, Hsin‐Hua Lui, Louis Tak Shaw, Suzun Tsai, Yu‐Lun |
author_facet | Yu, Pei‐Chieh Wu, Ching‐Jung Nien, Hsin‐Hua Lui, Louis Tak Shaw, Suzun Tsai, Yu‐Lun |
author_sort | Yu, Pei‐Chieh |
collection | PubMed |
description | PURPOSE: The purpose of this study is to introduce half‐beam volumetric‐modulated arc therapy (HVMAT), an innovative treatment planning technique from our work, for reducing dose to the organs at risk (OAR) during adjuvant radiotherapy for gynecological cancers. METHODS AND MATERIALS: Seventy‐two treatment plans of 36 patients with gynecological cancers receiving adjuvant radiotherapy were assessed. Among them, 36 plans were designed using HVMAT and paired with the other 36 traditional volumetric‐modulated arc therapy (VMAT) plans for each patient. The main uniqueness of the HVMAT designs was that it consisted of two opposite‐shielded half‐beam fields rotated inversely in two coplanar arcs, collocating with the specially‐devised avoidance structures to enhance the control of the OAR doses. The dose distributions in HVMAT and VMAT were evaluated and compared using the random effects model. RESULTS: The ratios of OAR doses in HVMAT compared with VMAT showed a comprehensive OAR dose reduction when using HVMAT (V (20Gy): bladder, 0.92; rectum, 0.95; V (30Gy): bowel, 0.91; femoral heads, 0.66), except for the ilium (V (30Gy): 1.12). The overall mean difference for each OAR across V (40Gy), V (30Gy), V (20Gy), and bowel V (15Gy) was statistically significant (almost all p < 0.001). In addition, HVMAT promoted a better conformity index, homogeneity index, D (2%), and V (107%) of the planning target volume (all p < 0.001). CONCLUSIONS: HVMAT is capable of generating deep double‐concave dose distributions with the advantage of reducing dose to several OARs simultaneously. It is highly recommended for pelvic irradiation, especially for treating gynecological cancers in adjuvant radiotherapy. |
format | Online Article Text |
id | pubmed-8803303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88033032022-02-04 Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers Yu, Pei‐Chieh Wu, Ching‐Jung Nien, Hsin‐Hua Lui, Louis Tak Shaw, Suzun Tsai, Yu‐Lun J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: The purpose of this study is to introduce half‐beam volumetric‐modulated arc therapy (HVMAT), an innovative treatment planning technique from our work, for reducing dose to the organs at risk (OAR) during adjuvant radiotherapy for gynecological cancers. METHODS AND MATERIALS: Seventy‐two treatment plans of 36 patients with gynecological cancers receiving adjuvant radiotherapy were assessed. Among them, 36 plans were designed using HVMAT and paired with the other 36 traditional volumetric‐modulated arc therapy (VMAT) plans for each patient. The main uniqueness of the HVMAT designs was that it consisted of two opposite‐shielded half‐beam fields rotated inversely in two coplanar arcs, collocating with the specially‐devised avoidance structures to enhance the control of the OAR doses. The dose distributions in HVMAT and VMAT were evaluated and compared using the random effects model. RESULTS: The ratios of OAR doses in HVMAT compared with VMAT showed a comprehensive OAR dose reduction when using HVMAT (V (20Gy): bladder, 0.92; rectum, 0.95; V (30Gy): bowel, 0.91; femoral heads, 0.66), except for the ilium (V (30Gy): 1.12). The overall mean difference for each OAR across V (40Gy), V (30Gy), V (20Gy), and bowel V (15Gy) was statistically significant (almost all p < 0.001). In addition, HVMAT promoted a better conformity index, homogeneity index, D (2%), and V (107%) of the planning target volume (all p < 0.001). CONCLUSIONS: HVMAT is capable of generating deep double‐concave dose distributions with the advantage of reducing dose to several OARs simultaneously. It is highly recommended for pelvic irradiation, especially for treating gynecological cancers in adjuvant radiotherapy. John Wiley and Sons Inc. 2021-11-16 /pmc/articles/PMC8803303/ /pubmed/34783436 http://dx.doi.org/10.1002/acm2.13472 Text en © 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Yu, Pei‐Chieh Wu, Ching‐Jung Nien, Hsin‐Hua Lui, Louis Tak Shaw, Suzun Tsai, Yu‐Lun Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title | Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title_full | Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title_fullStr | Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title_full_unstemmed | Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title_short | Half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
title_sort | half‐beam volumetric‐modulated arc therapy in adjuvant radiotherapy for gynecological cancers |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803303/ https://www.ncbi.nlm.nih.gov/pubmed/34783436 http://dx.doi.org/10.1002/acm2.13472 |
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