Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension

Sortilin has been positively correlated with vascular disorders in humans. No study has yet evaluated the possible direct effect of sortilin on vascular function. We used pharmacological and genetic approaches coupled with study of murine and human samples to unravel the mechanisms recruited by sort...

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Detalles Bibliográficos
Autores principales: Di Pietro, Paola, Carrizzo, Albino, Sommella, Eduardo, Oliveti, Marco, Iacoviello, Licia, Di Castelnuovo, Augusto, Acernese, Fausto, Damato, Antonio, De Lucia, Massimiliano, Merciai, Fabrizio, Iesu, Paola, Venturini, Eleonora, Izzo, Raffaele, Trimarco, Valentina, Ciccarelli, Michele, Giugliano, Giuseppe, Carnevale, Roberto, Cammisotto, Vittoria, Migliarino, Serena, Virtuoso, Nicola, Strianese, Andrea, Izzo, Viviana, Campiglia, Pietro, Ciaglia, Elena, Levkau, Bodo, Puca, Annibale A., Vecchione, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803332/
https://www.ncbi.nlm.nih.gov/pubmed/35104805
http://dx.doi.org/10.1172/JCI146343

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