Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

Desmoglein 1 (Dsg1) is a cadherin restricted to stratified tissues of terrestrial vertebrates, which serve as essential physical and immune barriers. Dsg1 loss-of-function mutations in humans result in skin lesions and multiple allergies, and isolated patient keratinocytes exhibit increased proaller...

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Detalles Bibliográficos
Autores principales: Godsel, Lisa M., Roth-Carter, Quinn R., Koetsier, Jennifer L., Tsoi, Lam C., Huffine, Amber L., Broussard, Joshua A., Fitz, Gillian N., Lloyd, Sarah M., Kweon, Junghun, Burks, Hope E., Hegazy, Marihan, Amagai, Saki, Harms, Paul W., Xing, Xianying, Kirma, Joseph, Johnson, Jodi L., Urciuoli, Gloria, Doglio, Lynn T., Swindell, William R., Awatramani, Rajeshwar, Sprecher, Eli, Bao, Xiaomin, Cohen-Barak, Eran, Missero, Caterina, Gudjonsson, Johann E., Green, Kathleen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803337/
https://www.ncbi.nlm.nih.gov/pubmed/34905516
http://dx.doi.org/10.1172/JCI144363

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