Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous no...

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Detalles Bibliográficos
Autores principales: Malik, Muhammad Nasir Hayat, Waqas, Syed Fakhar-ul-Hassnain, Zeitvogel, Jana, Cheng, Jingyuan, Geffers, Robert, Gouda, Zeinab Abu-Elbaha, Elsaman, Ahmed Mahrous, Radwan, Ahmed R., Schefzyk, Matthias, Braubach, Peter, Auber, Bernd, Olmer, Ruth, Müsken, Mathias, Roesner, Lennart M., Gerold, Gisa, Schuchardt, Sven, Merkert, Sylvia, Martin, Ulrich, Meissner, Felix, Werfel, Thomas, Pessler, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

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