Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous no...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Malik, Muhammad Nasir Hayat, Waqas, Syed Fakhar-ul-Hassnain, Zeitvogel, Jana, Cheng, Jingyuan, Geffers, Robert, Gouda, Zeinab Abu-Elbaha, Elsaman, Ahmed Mahrous, Radwan, Ahmed R., Schefzyk, Matthias, Braubach, Peter, Auber, Bernd, Olmer, Ruth, Müsken, Mathias, Roesner, Lennart M., Gerold, Gisa, Schuchardt, Sven, Merkert, Sylvia, Martin, Ulrich, Meissner, Felix, Werfel, Thomas, Pessler, Frank
Format: Online Artikel Text
Sprache:English
Veröffentlicht: American Society for Clinical Investigation 2022
Schlagworte:
Research Article
Online Zugang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

Online

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

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