Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous no...

תיאור מלא

מידע ביבליוגרפי
Autores principales: Malik, Muhammad Nasir Hayat, Waqas, Syed Fakhar-ul-Hassnain, Zeitvogel, Jana, Cheng, Jingyuan, Geffers, Robert, Gouda, Zeinab Abu-Elbaha, Elsaman, Ahmed Mahrous, Radwan, Ahmed R., Schefzyk, Matthias, Braubach, Peter, Auber, Bernd, Olmer, Ruth, Müsken, Mathias, Roesner, Lennart M., Gerold, Gisa, Schuchardt, Sven, Merkert, Sylvia, Martin, Ulrich, Meissner, Felix, Werfel, Thomas, Pessler, Frank
פורמט: Online Artículo Texto
שפה:English
יצא לאור: American Society for Clinical Investigation 2022
נושאים:
Research Article
גישה מקוונת:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

אינטרנט

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

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