Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous no...

Повний опис

Бібліографічні деталі
Автори: Malik, Muhammad Nasir Hayat, Waqas, Syed Fakhar-ul-Hassnain, Zeitvogel, Jana, Cheng, Jingyuan, Geffers, Robert, Gouda, Zeinab Abu-Elbaha, Elsaman, Ahmed Mahrous, Radwan, Ahmed R., Schefzyk, Matthias, Braubach, Peter, Auber, Bernd, Olmer, Ruth, Müsken, Mathias, Roesner, Lennart M., Gerold, Gisa, Schuchardt, Sven, Merkert, Sylvia, Martin, Ulrich, Meissner, Felix, Werfel, Thomas, Pessler, Frank
Формат: Online Стаття Текст
Мова:English
Опубліковано: American Society for Clinical Investigation 2022
Предмети:
Research Article
Онлайн доступ:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

Інтернет

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803340/
https://www.ncbi.nlm.nih.gov/pubmed/34847081
http://dx.doi.org/10.1172/JCI141573

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