Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Mutations in Dyrk1b are associated with metabolic syndrome and nonalcoholic fatty liver disease in humans. Our investigations showed that DYRK1B levels are increased in the liver of patients with nonalcoholic steatohepatitis (NASH) and in mice fed with a high-fat, high-sucrose diet. Increasing Dyrk1...

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Detalles Bibliográficos
Autores principales: Bhat, Neha, Narayanan, Anand, Fathzadeh, Mohsen, Kahn, Mario, Zhang, Dongyan, Goedeke, Leigh, Neogi, Arpita, Cardone, Rebecca L., Kibbey, Richard G., Fernandez-Hernando, Carlos, Ginsberg, Henry N., Jain, Dhanpat, Shulman, Gerald I., Mani, Arya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803348/
https://www.ncbi.nlm.nih.gov/pubmed/34855620
http://dx.doi.org/10.1172/JCI153724

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