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A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium

Aims: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures...

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Autores principales: Zaid, Maryam, Fujiyoshi, Akira, Hisamatsu, Takashi, Kadota, Aya, Kadowaki, Sayaka, Satoh, Atsushi, Sekikawa, Akira, Barinas-Mitchell, Emma, Horie, Minoru, Miura, Katsuyuki, Ueshima, Hirotsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803560/
https://www.ncbi.nlm.nih.gov/pubmed/33551394
http://dx.doi.org/10.5551/jat.61283
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author Zaid, Maryam
Fujiyoshi, Akira
Hisamatsu, Takashi
Kadota, Aya
Kadowaki, Sayaka
Satoh, Atsushi
Sekikawa, Akira
Barinas-Mitchell, Emma
Horie, Minoru
Miura, Katsuyuki
Ueshima, Hirotsugu
author_facet Zaid, Maryam
Fujiyoshi, Akira
Hisamatsu, Takashi
Kadota, Aya
Kadowaki, Sayaka
Satoh, Atsushi
Sekikawa, Akira
Barinas-Mitchell, Emma
Horie, Minoru
Miura, Katsuyuki
Ueshima, Hirotsugu
author_sort Zaid, Maryam
collection PubMed
description Aims: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. Methods: Japanese men aged 40-79y ( n =869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCA (mean) ), internal carotid artery (ICA (mean) ) and bifurcation (Bif (mean) ). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. Results: All cIMT measures had positive associations with CAC ( p <0.001): [OR, 95% Confidence Interval]: ICA (mean) [1.23, 1.07-1.42], CCA (mean) [1.27, 1.08-1.49], Bif (mean) [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile ( p <0.05), while CCA (mean) had some of the weakest associations among age quartiles. Conclusions: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCA (mean) , was no longer associated with coronary calcium after age-adjustment and stratification.
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spelling pubmed-88035602022-02-15 A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium Zaid, Maryam Fujiyoshi, Akira Hisamatsu, Takashi Kadota, Aya Kadowaki, Sayaka Satoh, Atsushi Sekikawa, Akira Barinas-Mitchell, Emma Horie, Minoru Miura, Katsuyuki Ueshima, Hirotsugu J Atheroscler Thromb Original Article Aims: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. Methods: Japanese men aged 40-79y ( n =869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCA (mean) ), internal carotid artery (ICA (mean) ) and bifurcation (Bif (mean) ). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. Results: All cIMT measures had positive associations with CAC ( p <0.001): [OR, 95% Confidence Interval]: ICA (mean) [1.23, 1.07-1.42], CCA (mean) [1.27, 1.08-1.49], Bif (mean) [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile ( p <0.05), while CCA (mean) had some of the weakest associations among age quartiles. Conclusions: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCA (mean) , was no longer associated with coronary calcium after age-adjustment and stratification. Japan Atherosclerosis Society 2022-02-01 2021-02-05 /pmc/articles/PMC8803560/ /pubmed/33551394 http://dx.doi.org/10.5551/jat.61283 Text en 2022 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Article
Zaid, Maryam
Fujiyoshi, Akira
Hisamatsu, Takashi
Kadota, Aya
Kadowaki, Sayaka
Satoh, Atsushi
Sekikawa, Akira
Barinas-Mitchell, Emma
Horie, Minoru
Miura, Katsuyuki
Ueshima, Hirotsugu
A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title_full A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title_fullStr A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title_full_unstemmed A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title_short A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium
title_sort comparison of segment-specific and composite measures of carotid intima-media thickness and their relationships with coronary calcium
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803560/
https://www.ncbi.nlm.nih.gov/pubmed/33551394
http://dx.doi.org/10.5551/jat.61283
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