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Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report

Langerhans cell sarcoma (LCS) is an extremely rare, malignant neoplasm that originates from Langerhans cells (LCs). Fewer than 70 cases have been reported in the English-language literature. LCS typically involves multiple organs, including the skin, lymph nodes, lungs, bone, bone marrow, liver, spl...

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Autores principales: Guo, Yu, Zhou, Shui-Hong, Cao, Zai-Zai, Bao, Yang-Yang, Shen, Li-Fang, Yao, Hong-Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803631/
https://www.ncbi.nlm.nih.gov/pubmed/35117987
http://dx.doi.org/10.3389/fonc.2021.769310
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author Guo, Yu
Zhou, Shui-Hong
Cao, Zai-Zai
Bao, Yang-Yang
Shen, Li-Fang
Yao, Hong-Tian
author_facet Guo, Yu
Zhou, Shui-Hong
Cao, Zai-Zai
Bao, Yang-Yang
Shen, Li-Fang
Yao, Hong-Tian
author_sort Guo, Yu
collection PubMed
description Langerhans cell sarcoma (LCS) is an extremely rare, malignant neoplasm that originates from Langerhans cells (LCs). Fewer than 70 cases have been reported in the English-language literature. LCS typically involves multiple organs, including the skin, lymph nodes, lungs, bone, bone marrow, liver, spleen, and soft tissues. Several etiological factors for LCS have been proposed, including immunosuppression, virus infection, and prior hematological disease. We report a rare case of LCS with Epstein–Barr virus (EBV) infection; bilateral cervical giant cysts were the initial manifestation. To our knowledge, this is the first report of LCS with EBV infection. The case information was complete, and the relevant literature was reviewed to gain insight into LCS. The case raises new questions on the oncogenic character of EBV.
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spelling pubmed-88036312022-02-02 Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report Guo, Yu Zhou, Shui-Hong Cao, Zai-Zai Bao, Yang-Yang Shen, Li-Fang Yao, Hong-Tian Front Oncol Oncology Langerhans cell sarcoma (LCS) is an extremely rare, malignant neoplasm that originates from Langerhans cells (LCs). Fewer than 70 cases have been reported in the English-language literature. LCS typically involves multiple organs, including the skin, lymph nodes, lungs, bone, bone marrow, liver, spleen, and soft tissues. Several etiological factors for LCS have been proposed, including immunosuppression, virus infection, and prior hematological disease. We report a rare case of LCS with Epstein–Barr virus (EBV) infection; bilateral cervical giant cysts were the initial manifestation. To our knowledge, this is the first report of LCS with EBV infection. The case information was complete, and the relevant literature was reviewed to gain insight into LCS. The case raises new questions on the oncogenic character of EBV. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8803631/ /pubmed/35117987 http://dx.doi.org/10.3389/fonc.2021.769310 Text en Copyright © 2022 Guo, Zhou, Cao, Bao, Shen and Yao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Guo, Yu
Zhou, Shui-Hong
Cao, Zai-Zai
Bao, Yang-Yang
Shen, Li-Fang
Yao, Hong-Tian
Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title_full Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title_fullStr Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title_full_unstemmed Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title_short Epstein–Barr Virus-Positive Langerhans Cell Sarcoma: Is There a Link? A Case Report
title_sort epstein–barr virus-positive langerhans cell sarcoma: is there a link? a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803631/
https://www.ncbi.nlm.nih.gov/pubmed/35117987
http://dx.doi.org/10.3389/fonc.2021.769310
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