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Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients
The anatomical relationship between speech apraxia (SA) and oral apraxia (OA) is still unclear. To shed light on this matter we studied 137 patients with acute ischaemic left-hemisphere stroke and performed support vector regression-based, multivariate lesion–symptom mapping. Thirty-three patients p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803819/ https://www.ncbi.nlm.nih.gov/pubmed/34652492 http://dx.doi.org/10.1007/s00221-021-06224-3 |
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author | Conterno, Martina Kümmerer, Dorothee Dressing, Andrea Glauche, Volkmar Urbach, Horst Weiller, Cornelius Rijntjes, Michel |
author_facet | Conterno, Martina Kümmerer, Dorothee Dressing, Andrea Glauche, Volkmar Urbach, Horst Weiller, Cornelius Rijntjes, Michel |
author_sort | Conterno, Martina |
collection | PubMed |
description | The anatomical relationship between speech apraxia (SA) and oral apraxia (OA) is still unclear. To shed light on this matter we studied 137 patients with acute ischaemic left-hemisphere stroke and performed support vector regression-based, multivariate lesion–symptom mapping. Thirty-three patients presented with either SA or OA. These two symptoms mostly co-occurred (n = 28), except for few patients with isolated SA (n = 2) or OA (n = 3). All patient with either SA or OA presented with aphasia (p < 0.001) and these symptoms were highly associated with apraxia (p < 0.001). Co-occurring SA and OA were predominantly associated with insular lesions, while the insula was completely spared in the five patients with isolated SA or OA. Isolated SA occurred in case of frontal lesions (prefrontal gyrus and superior longitudinal fasciculus), while isolated OA occurred in case of either temporoparietal or striatocapsular lesions. Our study supports the notion of a predominant, but not exclusive, role of the insula in verbal and non-verbal oral praxis, and indicates that frontal regions may contribute exclusively to verbal oral praxis, while temporoparietal and striatocapsular regions contribute to non-verbal oral praxis. However, since tests for SA and OA so far intrinsically also investigate aphasia and apraxia, refined tests are warranted. |
format | Online Article Text |
id | pubmed-8803819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88038192022-02-02 Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients Conterno, Martina Kümmerer, Dorothee Dressing, Andrea Glauche, Volkmar Urbach, Horst Weiller, Cornelius Rijntjes, Michel Exp Brain Res Research Article The anatomical relationship between speech apraxia (SA) and oral apraxia (OA) is still unclear. To shed light on this matter we studied 137 patients with acute ischaemic left-hemisphere stroke and performed support vector regression-based, multivariate lesion–symptom mapping. Thirty-three patients presented with either SA or OA. These two symptoms mostly co-occurred (n = 28), except for few patients with isolated SA (n = 2) or OA (n = 3). All patient with either SA or OA presented with aphasia (p < 0.001) and these symptoms were highly associated with apraxia (p < 0.001). Co-occurring SA and OA were predominantly associated with insular lesions, while the insula was completely spared in the five patients with isolated SA or OA. Isolated SA occurred in case of frontal lesions (prefrontal gyrus and superior longitudinal fasciculus), while isolated OA occurred in case of either temporoparietal or striatocapsular lesions. Our study supports the notion of a predominant, but not exclusive, role of the insula in verbal and non-verbal oral praxis, and indicates that frontal regions may contribute exclusively to verbal oral praxis, while temporoparietal and striatocapsular regions contribute to non-verbal oral praxis. However, since tests for SA and OA so far intrinsically also investigate aphasia and apraxia, refined tests are warranted. Springer Berlin Heidelberg 2021-10-15 2022 /pmc/articles/PMC8803819/ /pubmed/34652492 http://dx.doi.org/10.1007/s00221-021-06224-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Conterno, Martina Kümmerer, Dorothee Dressing, Andrea Glauche, Volkmar Urbach, Horst Weiller, Cornelius Rijntjes, Michel Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title | Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title_full | Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title_fullStr | Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title_full_unstemmed | Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title_short | Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion–symptom mapping study in acute stroke patients |
title_sort | speech apraxia and oral apraxia: association or dissociation? a multivariate lesion–symptom mapping study in acute stroke patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803819/ https://www.ncbi.nlm.nih.gov/pubmed/34652492 http://dx.doi.org/10.1007/s00221-021-06224-3 |
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