Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma

As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors w...

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Detalles Bibliográficos
Autores principales: Berlo, K., Xia, W., Zwillich, F., Gibbons, E., Gaudiuso, R., Ewusi-Annan, E., Chiklis, G. R., Melikechi, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803875/
https://www.ncbi.nlm.nih.gov/pubmed/35102204
http://dx.doi.org/10.1038/s41598-022-05509-z
Descripción
Sumario:As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.

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