Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma

As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors w...

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Autores principales: Berlo, K., Xia, W., Zwillich, F., Gibbons, E., Gaudiuso, R., Ewusi-Annan, E., Chiklis, G. R., Melikechi, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803875/
https://www.ncbi.nlm.nih.gov/pubmed/35102204
http://dx.doi.org/10.1038/s41598-022-05509-z
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author Berlo, K.
Xia, W.
Zwillich, F.
Gibbons, E.
Gaudiuso, R.
Ewusi-Annan, E.
Chiklis, G. R.
Melikechi, N.
author_facet Berlo, K.
Xia, W.
Zwillich, F.
Gibbons, E.
Gaudiuso, R.
Ewusi-Annan, E.
Chiklis, G. R.
Melikechi, N.
author_sort Berlo, K.
collection PubMed
description As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.
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spelling pubmed-88038752022-02-01 Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma Berlo, K. Xia, W. Zwillich, F. Gibbons, E. Gaudiuso, R. Ewusi-Annan, E. Chiklis, G. R. Melikechi, N. Sci Rep Article As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra. Nature Publishing Group UK 2022-01-31 /pmc/articles/PMC8803875/ /pubmed/35102204 http://dx.doi.org/10.1038/s41598-022-05509-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Berlo, K.
Xia, W.
Zwillich, F.
Gibbons, E.
Gaudiuso, R.
Ewusi-Annan, E.
Chiklis, G. R.
Melikechi, N.
Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title_full Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title_fullStr Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title_full_unstemmed Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title_short Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma
title_sort laser induced breakdown spectroscopy for the rapid detection of sars-cov-2 immune response in plasma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803875/
https://www.ncbi.nlm.nih.gov/pubmed/35102204
http://dx.doi.org/10.1038/s41598-022-05509-z
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