Cargando…

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng

The medicinal properties of Ashwagandha (Withania somnifera) are attributed to triterpenoid steroidal lactones, withanolides, which are proposed to be derived from phytosterol pathway, through the action of cytochrome P450 (CYP450) enzymes. Here, we report the characterization of three transcriptome...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shilpashree, H. B., Sudharshan, S. J., Shasany, Ajit K., Nagegowda, Dinesh A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803918/ https://www.ncbi.nlm.nih.gov/pubmed/35102209 http://dx.doi.org/10.1038/s41598-022-05634-9

Ejemplares similares

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
por: Lee, Seoung Rak, et al.
Publicado: (2022)

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis
por: Pandey, Shiv S., et al.
Publicado: (2018)

Comparative interactions of withanolides and sterols with two members of sterol glycosyltransferases from Withania somnifera
por: Pandey, Vibha, et al.
Publicado: (2015)

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system
por: Devkar, Santosh T., et al.
Publicado: (2015)

Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities
por: Ha, Ji Won, et al.
Publicado: (2022)

Silencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somnifera
por: Singh, Gaurav, et al.
Publicado: (2016)

Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Withania somnifera)
por: Lee, Bum Soo, et al.
Publicado: (2021)

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)
por: Singh, Manali, et al.
Publicado: (2022)

Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera)
por: Baek, Su Cheol, et al.
Publicado: (2019)

Investigating 11 Withanosides and Withanolides by UHPLC–PDA and Mass Fragmentation Studies from Ashwagandha (Withania somnifera)
por: Girme, Aboli, et al.
Publicado: (2020)

Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations
por: Rana, Satiander, et al.
Publicado: (2014)

Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera
por: Gupta, Parul, et al.
Publicado: (2015)

Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal
por: Thorat, Sachin Ashok, et al.
Publicado: (2022)

Withania Coagulans and Somnifera
por: Verghese, M.
Publicado: (1885)

Transcription factor repertoire in Ashwagandha (Withania somnifera) through analytics of transcriptomic resources: Insights into regulation of development and withanolide metabolism
por: Tripathi, Sandhya, et al.
Publicado: (2017)

Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice
por: Dey, Amitabha, et al.
Publicado: (2018)

A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering
por: Dhar, Niha, et al.
Publicado: (2015)

Transcriptome analysis reveals in vitro cultured Withania somnifera leaf and root tissues as a promising source for targeted withanolide biosynthesis
por: Senthil, Kalaiselvi, et al.
Publicado: (2015)

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture
por: Singh, Manali, et al.
Publicado: (2023)

Influence of phytochemical composition on in vitro antioxidant and reducing activities of Indian ginseng [Withania somnifera (L.) Dunal] root extracts
por: Ganguly, Bhaskar, et al.
Publicado: (2018)

Altered biomass allocation and quality improvement in roots of Indian ginseng Withania somnifera Dunal. Linn. through physiological interventions
por: Kalariya, Kuldeepsingh A., et al.
Publicado: (2020)

Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells
por: Lee, Dahae, et al.
Publicado: (2022)

Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor
por: Sivanandhan, Ganeshan, et al.
Publicado: (2014)

In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera
por: Singh, Manjeet, et al.
Publicado: (2017)

De Novo Assembly, Functional Annotation and Comparative Analysis of Withania somnifera Leaf and Root Transcriptomes to Identify Putative Genes Involved in the Withanolides Biosynthesis
por: Gupta, Parul, et al.
Publicado: (2013)

Evaluation of Indian ginseng [Withania somnifera (L.) Dunal] breeding lines and genotype-by-environment interaction across production environments in western India
por: Kumar, Mithlesh, et al.
Publicado: (2023)

RNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somnifera
por: Mishra, Smrati, et al.
Publicado: (2016)

Ashwagandha (Withania somnifera) supercritical CO(2) extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells
por: Vidyashankar, Satyakumar, et al.
Publicado: (2014)

Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS)
por: Modi, Siddharth J., et al.
Publicado: (2022)

Genetic variability, associations, and path analysis of chemical and morphological traits in Indian ginseng [Withania somnifera (L.) Dunal] for selection of higher yielding genotypes
por: Srivastava, Abhilasha, et al.
Publicado: (2018)

Protective Effects of Withagenin A Diglucoside from Indian Ginseng (Withania somnifera) against Human Dermal Fibroblast Damaged by TNF-α Stimulation
por: Lee, Sullim, et al.
Publicado: (2022)

In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19
por: Kasarla, Siva Swapna, et al.
Publicado: (2022)

Nutritional enrichment of broiler breast meat through dietary supplementation of Indian ginseng Withania somnifera and synbiotic substances under semi-arid climatic conditions
por: Thakur, Sonal, et al.
Publicado: (2017)

Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides
por: Holvoet, Helen, et al.
Publicado: (2022)

Evaluation of Antimicrobial Efficacy of Flavonoids of Withania Somnifera L.
por: Singh, G., et al.
Publicado: (2011)

Efficacy of Withania somnifera supplementation on adult’s cognition and mood
por: Remenapp, A., et al.
Publicado: (2022)

Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation
por: Maher, Saima, et al.
Publicado: (2020)

Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents
por: Moujir, Laila M., et al.
Publicado: (2020)

Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice
por: Padmavathi, Bandhuvula, et al.
Publicado: (2005)

FREE RADICAL SCAVENGING ACTIVITY OF DIFFERENT PARTS OF WITHANIA SOMNIFERA
por: Sumathi, S., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_kjp7bcfb20ihn5bfq9v7ogntgo