Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients

Cystic fibrosis (CF) is a severe genetic disorder that can cause multiple comorbidities affecting the lungs, the pancreas, the luminal digestive system and beyond. In our previous genome-wide association studies (GWAS), we genotyped approximately 8,000 CF samples using a mixture of different genotyp...

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Detalles Bibliográficos
Autores principales: Sun, Quan, Liu, Weifang, Rosen, Jonathan D., Huang, Le, Pace, Rhonda G., Dang, Hong, Gallins, Paul J., Blue, Elizabeth E., Ling, Hua, Corvol, Harriet, Strug, Lisa J., Bamshad, Michael J., Gibson, Ronald L., Pugh, Elizabeth W., Blackman, Scott M., Cutting, Garry R., O'Neal, Wanda K., Zhou, Yi-Hui, Wright, Fred A., Knowles, Michael R., Wen, Jia, Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804187/
https://www.ncbi.nlm.nih.gov/pubmed/35128485
http://dx.doi.org/10.1016/j.xhgg.2022.100090

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