Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

Oncogenic multidrug resistance is commonly intrinsic to renal cancer based on the physiological expression of detoxification transporters, particularly ABCB1, thus hampering chemotherapy. ABCB1 activity is directly dependent on its lipid microenvironment, localizing to cholesterol- and sphingomyelin...

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Detalles Bibliográficos
Autores principales: Lee, Wing-Kee, Maaß, Michelle, Quach, Amy, Poscic, Nataliya, Prangley, Holly, Pallott, Erin-Claire, Kim, Jiyoon L., Pierce, Jason S., Ogretmen, Besim, Futerman, Anthony H., Thévenod, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804196/
https://www.ncbi.nlm.nih.gov/pubmed/34915026
http://dx.doi.org/10.1016/j.jbc.2021.101492

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