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Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports

Observations of short-term changes in the neural health of youth athletes participating in collision sports (e.g., football and soccer) have highlighted a need to explore potential structural alterations in brain tissue volumes for these persons. Studies have shown biochemical, vascular, functional...

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Autores principales: Kashyap, Pratik, Shenk, Trey E., Svaldi, Diana O., Lycke, Roy J., Lee, Taylor A., Tamer, Gregory G., Nauman, Eric A., Talavage, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804236/
https://www.ncbi.nlm.nih.gov/pubmed/35112108
http://dx.doi.org/10.1089/neur.2021.0060
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author Kashyap, Pratik
Shenk, Trey E.
Svaldi, Diana O.
Lycke, Roy J.
Lee, Taylor A.
Tamer, Gregory G.
Nauman, Eric A.
Talavage, Thomas M.
author_facet Kashyap, Pratik
Shenk, Trey E.
Svaldi, Diana O.
Lycke, Roy J.
Lee, Taylor A.
Tamer, Gregory G.
Nauman, Eric A.
Talavage, Thomas M.
author_sort Kashyap, Pratik
collection PubMed
description Observations of short-term changes in the neural health of youth athletes participating in collision sports (e.g., football and soccer) have highlighted a need to explore potential structural alterations in brain tissue volumes for these persons. Studies have shown biochemical, vascular, functional connectivity, and white matter diffusivity changes in the brain physiology of these athletes that are strongly correlated with repetitive head acceleration exposure. Here, research is presented that highlights regional anatomical volumetric measures that change longitudinally with accrued subconcussive trauma. A novel pipeline is introduced that provides simplified data analysis on standard-space template to quantify group-level longitudinal volumetric changes within these populations. For both sports, results highlight incremental relative regional volumetric changes in the subcortical cerebrospinal fluid that are strongly correlated with head exposure events greater than a 50-G threshold at the short-term post-season assessment. Moreover, longitudinal regional gray matter volumes are observed to decrease with time, only returning to baseline/pre-participation levels after sufficient (5–6 months) rest from collision-based exposure. These temporal structural volumetric alterations are significantly different from normal aging observed in sex- and age-matched controls participating in non-collision sports. Future work involves modeling repetitive head exposure thresholds with multi-modal image analysis and understanding the underlying physiological reason. A possible pathophysiological pathway is presented, highlighting the probable metabolic regulatory mechanisms. Continual participation in collision-based activities may represent a risk wherein recovery cannot occur. Even when present, the degree of the eventual recovery remains to be explored, but has strong implications for the well-being of collision-sport participants.
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spelling pubmed-88042362022-02-01 Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports Kashyap, Pratik Shenk, Trey E. Svaldi, Diana O. Lycke, Roy J. Lee, Taylor A. Tamer, Gregory G. Nauman, Eric A. Talavage, Thomas M. Neurotrauma Rep Original Article Observations of short-term changes in the neural health of youth athletes participating in collision sports (e.g., football and soccer) have highlighted a need to explore potential structural alterations in brain tissue volumes for these persons. Studies have shown biochemical, vascular, functional connectivity, and white matter diffusivity changes in the brain physiology of these athletes that are strongly correlated with repetitive head acceleration exposure. Here, research is presented that highlights regional anatomical volumetric measures that change longitudinally with accrued subconcussive trauma. A novel pipeline is introduced that provides simplified data analysis on standard-space template to quantify group-level longitudinal volumetric changes within these populations. For both sports, results highlight incremental relative regional volumetric changes in the subcortical cerebrospinal fluid that are strongly correlated with head exposure events greater than a 50-G threshold at the short-term post-season assessment. Moreover, longitudinal regional gray matter volumes are observed to decrease with time, only returning to baseline/pre-participation levels after sufficient (5–6 months) rest from collision-based exposure. These temporal structural volumetric alterations are significantly different from normal aging observed in sex- and age-matched controls participating in non-collision sports. Future work involves modeling repetitive head exposure thresholds with multi-modal image analysis and understanding the underlying physiological reason. A possible pathophysiological pathway is presented, highlighting the probable metabolic regulatory mechanisms. Continual participation in collision-based activities may represent a risk wherein recovery cannot occur. Even when present, the degree of the eventual recovery remains to be explored, but has strong implications for the well-being of collision-sport participants. Mary Ann Liebert, Inc., publishers 2022-01-28 /pmc/articles/PMC8804236/ /pubmed/35112108 http://dx.doi.org/10.1089/neur.2021.0060 Text en © Pratik Kashyap et al., 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kashyap, Pratik
Shenk, Trey E.
Svaldi, Diana O.
Lycke, Roy J.
Lee, Taylor A.
Tamer, Gregory G.
Nauman, Eric A.
Talavage, Thomas M.
Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title_full Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title_fullStr Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title_full_unstemmed Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title_short Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports
title_sort normalized brain tissue–level evaluation of volumetric changes of youth athletes participating in collision sports
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804236/
https://www.ncbi.nlm.nih.gov/pubmed/35112108
http://dx.doi.org/10.1089/neur.2021.0060
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