Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death

Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. Ferroptosis is triggered by oxidation of polyunsatu...

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Detalles Bibliográficos
Autores principales: Lamade, Andrew M., Wu, Limin, Dar, Haider H., Mentrup, Heather L., Shrivastava, Indira H., Epperly, Michael W., St Croix, Claudette M., Tyurina, Yulia Y., Anthonymuthu, Tamil S., Yang, Qin, Kapralov, Aleksandr A., Huang, Zhentai, Mao, Gaowei, Amoscato, Andrew A., Hier, Zachary E., Artyukhova, Margarita A., Shurin, Galina, Rosenbaum, Joel C., Gough, Peter J., Bertin, John, VanDemark, Andrew P., Watkins, Simon C., Mollen, Kevin P., Bahar, Ivet, Greenberger, Joel S., Kagan, Valerian E., Whalen, Michael J., Bayır, Hülya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804265/
https://www.ncbi.nlm.nih.gov/pubmed/35101798
http://dx.doi.org/10.1016/j.redox.2022.102232

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