Dynamic changes in β-cell [Ca(2+)] regulate NFAT activation, gene transcription, and islet gap junction communication

OBJECTIVE: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca(2+) ([Ca(2+)]) oscillations, which trigger insulin re...

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Detalles Bibliográficos
Autores principales: Miranda, Jose G., Schleicher, Wolfgang E., Wells, Kristen L., Ramirez, David G., Landgrave, Samantha P., Benninger, Richard K.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804269/
https://www.ncbi.nlm.nih.gov/pubmed/34979329
http://dx.doi.org/10.1016/j.molmet.2021.101430

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