Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

BACKGROUND & AIMS: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2(-/-) mice replicate the human phenotype but were not suitable for detailed mechanistic studies...

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Detalles Bibliográficos
Autores principales: Luo, Fei, Smagris, Eriks, Martin, Sarah A., Vale, Goncalo, McDonald, Jeffrey G., Fletcher, Justin A., Burgess, Shawn C., Hobbs, Helen H., Cohen, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804273/
https://www.ncbi.nlm.nih.gov/pubmed/34923175
http://dx.doi.org/10.1016/j.jcmgh.2021.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804273/
https://www.ncbi.nlm.nih.gov/pubmed/34923175
http://dx.doi.org/10.1016/j.jcmgh.2021.12.008

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