Cargando…
A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension
Pulmonary hypertension (PH) is a clinical condition characterized by progressive elevations in mean pulmonary artery pressures and right ventricular dysfunction, associated with significant morbidity and mortality. For resting PH to develop, ~50–70% of the pulmonary vasculature must be affected, sug...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804287/ https://www.ncbi.nlm.nih.gov/pubmed/35118142 http://dx.doi.org/10.3389/fcvm.2021.794706 |
_version_ | 1784643043913105408 |
---|---|
author | Farrell, Christine Balasubramanian, Aparna Hays, Allison G. Hsu, Steven Rowe, Steven Zimmerman, Stefan L. Hassoun, Paul M. Mathai, Stephen C. Mukherjee, Monica |
author_facet | Farrell, Christine Balasubramanian, Aparna Hays, Allison G. Hsu, Steven Rowe, Steven Zimmerman, Stefan L. Hassoun, Paul M. Mathai, Stephen C. Mukherjee, Monica |
author_sort | Farrell, Christine |
collection | PubMed |
description | Pulmonary hypertension (PH) is a clinical condition characterized by progressive elevations in mean pulmonary artery pressures and right ventricular dysfunction, associated with significant morbidity and mortality. For resting PH to develop, ~50–70% of the pulmonary vasculature must be affected, suggesting that even mild hemodynamic abnormalities are representative of advanced pulmonary vascular disease. The definitive diagnosis of PH is based upon hemodynamics measured by right heart catheterization; however this is an invasive and resource intense study. Early identification of pulmonary vascular disease offers the opportunity to improve outcomes by instituting therapies that slow, reverse, or potentially prevent this devastating disease. Multimodality imaging, including non-invasive modalities such as echocardiography, computed tomography, ventilation perfusion scans, and cardiac magnetic resonance imaging, has emerged as an integral tool for screening, classifying, prognosticating, and monitoring response to therapy in PH. Additionally, novel imaging modalities such as echocardiographic strain imaging, 3D echocardiography, dual energy CT, FDG-PET, and 4D flow MRI are actively being investigated to assess the severity of right ventricular dysfunction in PH. In this review, we will describe the utility and clinical application of multimodality imaging techniques across PH subtypes as it pertains to screening and monitoring of PH. |
format | Online Article Text |
id | pubmed-8804287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88042872022-02-02 A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension Farrell, Christine Balasubramanian, Aparna Hays, Allison G. Hsu, Steven Rowe, Steven Zimmerman, Stefan L. Hassoun, Paul M. Mathai, Stephen C. Mukherjee, Monica Front Cardiovasc Med Cardiovascular Medicine Pulmonary hypertension (PH) is a clinical condition characterized by progressive elevations in mean pulmonary artery pressures and right ventricular dysfunction, associated with significant morbidity and mortality. For resting PH to develop, ~50–70% of the pulmonary vasculature must be affected, suggesting that even mild hemodynamic abnormalities are representative of advanced pulmonary vascular disease. The definitive diagnosis of PH is based upon hemodynamics measured by right heart catheterization; however this is an invasive and resource intense study. Early identification of pulmonary vascular disease offers the opportunity to improve outcomes by instituting therapies that slow, reverse, or potentially prevent this devastating disease. Multimodality imaging, including non-invasive modalities such as echocardiography, computed tomography, ventilation perfusion scans, and cardiac magnetic resonance imaging, has emerged as an integral tool for screening, classifying, prognosticating, and monitoring response to therapy in PH. Additionally, novel imaging modalities such as echocardiographic strain imaging, 3D echocardiography, dual energy CT, FDG-PET, and 4D flow MRI are actively being investigated to assess the severity of right ventricular dysfunction in PH. In this review, we will describe the utility and clinical application of multimodality imaging techniques across PH subtypes as it pertains to screening and monitoring of PH. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8804287/ /pubmed/35118142 http://dx.doi.org/10.3389/fcvm.2021.794706 Text en Copyright © 2022 Farrell, Balasubramanian, Hays, Hsu, Rowe, Zimmerman, Hassoun, Mathai and Mukherjee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Farrell, Christine Balasubramanian, Aparna Hays, Allison G. Hsu, Steven Rowe, Steven Zimmerman, Stefan L. Hassoun, Paul M. Mathai, Stephen C. Mukherjee, Monica A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title | A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title_full | A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title_fullStr | A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title_full_unstemmed | A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title_short | A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension |
title_sort | clinical approach to multimodality imaging in pulmonary hypertension |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804287/ https://www.ncbi.nlm.nih.gov/pubmed/35118142 http://dx.doi.org/10.3389/fcvm.2021.794706 |
work_keys_str_mv | AT farrellchristine aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT balasubramanianaparna aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT haysallisong aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT hsusteven aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT rowesteven aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT zimmermanstefanl aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT hassounpaulm aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT mathaistephenc aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT mukherjeemonica aclinicalapproachtomultimodalityimaginginpulmonaryhypertension AT farrellchristine clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT balasubramanianaparna clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT haysallisong clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT hsusteven clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT rowesteven clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT zimmermanstefanl clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT hassounpaulm clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT mathaistephenc clinicalapproachtomultimodalityimaginginpulmonaryhypertension AT mukherjeemonica clinicalapproachtomultimodalityimaginginpulmonaryhypertension |