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Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish

Meclozine has been developed as an inhibitor of fibroblast growth factor receptor 3 (FGFR3) to treat achondroplasia (ACH). Extracellular signal regulated kinase (ERK) phosphorylation was attenuated by meclozine in FGF2-treated chondrocyte cell line, but the site of its action has not been elucidated...

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Detalles Bibliográficos
Autores principales:	Takemoto, Genta, Matsushita, Masaki, Okamoto, Takaaki, Ito, Toshinari, Matsuura, Yuki, Takashima, Chieko, Chen-Yoshikawa, Toyofumi Fengshi, Ebi, Hiromichi, Imagama, Shiro, Kitoh, Hiroshi, Ohno, Kinji, Hosono, Yasuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804316/ https://www.ncbi.nlm.nih.gov/pubmed/35118060 http://dx.doi.org/10.3389/fcell.2021.694018

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