Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies...

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Autores principales: Shen, Qiyang, Liu, Xingyu, Li, Wei, Zhao, Xu, Li, Tao, Zhou, Kai, Zhou, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804321/
https://www.ncbi.nlm.nih.gov/pubmed/35116058
http://dx.doi.org/10.3389/fgene.2021.820936
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author Shen, Qiyang
Liu, Xingyu
Li, Wei
Zhao, Xu
Li, Tao
Zhou, Kai
Zhou, Jianfeng
author_facet Shen, Qiyang
Liu, Xingyu
Li, Wei
Zhao, Xu
Li, Tao
Zhou, Kai
Zhou, Jianfeng
author_sort Shen, Qiyang
collection PubMed
description Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.
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spelling pubmed-88043212022-02-02 Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors Shen, Qiyang Liu, Xingyu Li, Wei Zhao, Xu Li, Tao Zhou, Kai Zhou, Jianfeng Front Genet Genetics Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8804321/ /pubmed/35116058 http://dx.doi.org/10.3389/fgene.2021.820936 Text en Copyright © 2022 Shen, Liu, Li, Zhao, Li, Zhou and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Shen, Qiyang
Liu, Xingyu
Li, Wei
Zhao, Xu
Li, Tao
Zhou, Kai
Zhou, Jianfeng
Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title_full Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title_fullStr Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title_full_unstemmed Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title_short Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
title_sort emerging role and mechanism of circrnas in pediatric malignant solid tumors
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804321/
https://www.ncbi.nlm.nih.gov/pubmed/35116058
http://dx.doi.org/10.3389/fgene.2021.820936
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