Cargando…

The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma

PURPOSE: To explore the prognostic impact of combined tumor-infiltrating lymphocytes (TILs) and pretreatment peripheral lymphocyte percentage (LYM%) among patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS: TILs and pretreatment LYM% were retrospectively assessed...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Zhuochen, Jiang, Jiali, Huang, Laiji, Yuan, Yawei, Zheng, Ronghui, Zhang, Jiangyu, Qiu, Wenze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804347/
https://www.ncbi.nlm.nih.gov/pubmed/35117992
http://dx.doi.org/10.3389/fonc.2021.788497
_version_ 1784643057051762688
author Cai, Zhuochen
Jiang, Jiali
Huang, Laiji
Yuan, Yawei
Zheng, Ronghui
Zhang, Jiangyu
Qiu, Wenze
author_facet Cai, Zhuochen
Jiang, Jiali
Huang, Laiji
Yuan, Yawei
Zheng, Ronghui
Zhang, Jiangyu
Qiu, Wenze
author_sort Cai, Zhuochen
collection PubMed
description PURPOSE: To explore the prognostic impact of combined tumor-infiltrating lymphocytes (TILs) and pretreatment peripheral lymphocyte percentage (LYM%) among patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS: TILs and pretreatment LYM% were retrospectively assessed in 253 LA-NPC patients who underwent chemoradiation therapy between January 2012 and December 2017. According to TILs and LYM% status, the patients were divided into three groups: high-risk group (HRG) (TILs–LYM% score = 0), middle-risk group (MRG) (TILs–LYM% score = 1), and low-risk group (LRG) (TILs–LYM% score = 2). The relationship between TILs level and LYM%, and also the associations of TILs–LYM% status with clinicopathological factors and survival, were evaluated. RESULTS: As a continuous variable, LYM% was significantly higher in TILs-high group. High TILs or high LYM% alone was significantly related to better 3-year disease-free survival (DFS), overall survival (OS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS), respectively. Kaplan–Meier analysis and log-rank tests also revealed significant decreases in DFS, OS, DMFS, and LRRFS among LA-NPC patients with TILs–LYM% score of 0, 1, and 2 (all P <0.05). Further multivariate analyses showed that TILs–LYM% score was an independent factor affecting survival of the patients, and HRG (TILs–LYM% score = 0) had increased hazard ratios (HRs) for disease (HR = 6.89, P <0.001), death (HR = 8.08, P = 0.008), distant metastasis (HR = 7.66, P = 0.001), and local relapse (HR = 5.18, P = 0.013) compared with LRG (TILs–LYM% score = 2). In receiver operating characteristics (ROC) analyses, TILs–LYM% score had a higher area under the ROC curve (AUC) for the prediction of DFS than did TILs or LYM% alone. CONCLUSIONS: A positive correlation was found between TILs level and pretreatment blood lymphocyte percentage. Moreover, TILs–LYM% score can be considered as a novel independent prognostic indicator of survival outcome among patients with LA-NPC.
format Online
Article
Text
id pubmed-8804347
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88043472022-02-02 The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma Cai, Zhuochen Jiang, Jiali Huang, Laiji Yuan, Yawei Zheng, Ronghui Zhang, Jiangyu Qiu, Wenze Front Oncol Oncology PURPOSE: To explore the prognostic impact of combined tumor-infiltrating lymphocytes (TILs) and pretreatment peripheral lymphocyte percentage (LYM%) among patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS: TILs and pretreatment LYM% were retrospectively assessed in 253 LA-NPC patients who underwent chemoradiation therapy between January 2012 and December 2017. According to TILs and LYM% status, the patients were divided into three groups: high-risk group (HRG) (TILs–LYM% score = 0), middle-risk group (MRG) (TILs–LYM% score = 1), and low-risk group (LRG) (TILs–LYM% score = 2). The relationship between TILs level and LYM%, and also the associations of TILs–LYM% status with clinicopathological factors and survival, were evaluated. RESULTS: As a continuous variable, LYM% was significantly higher in TILs-high group. High TILs or high LYM% alone was significantly related to better 3-year disease-free survival (DFS), overall survival (OS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS), respectively. Kaplan–Meier analysis and log-rank tests also revealed significant decreases in DFS, OS, DMFS, and LRRFS among LA-NPC patients with TILs–LYM% score of 0, 1, and 2 (all P <0.05). Further multivariate analyses showed that TILs–LYM% score was an independent factor affecting survival of the patients, and HRG (TILs–LYM% score = 0) had increased hazard ratios (HRs) for disease (HR = 6.89, P <0.001), death (HR = 8.08, P = 0.008), distant metastasis (HR = 7.66, P = 0.001), and local relapse (HR = 5.18, P = 0.013) compared with LRG (TILs–LYM% score = 2). In receiver operating characteristics (ROC) analyses, TILs–LYM% score had a higher area under the ROC curve (AUC) for the prediction of DFS than did TILs or LYM% alone. CONCLUSIONS: A positive correlation was found between TILs level and pretreatment blood lymphocyte percentage. Moreover, TILs–LYM% score can be considered as a novel independent prognostic indicator of survival outcome among patients with LA-NPC. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8804347/ /pubmed/35117992 http://dx.doi.org/10.3389/fonc.2021.788497 Text en Copyright © 2022 Cai, Jiang, Huang, Yuan, Zheng, Zhang and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cai, Zhuochen
Jiang, Jiali
Huang, Laiji
Yuan, Yawei
Zheng, Ronghui
Zhang, Jiangyu
Qiu, Wenze
The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title_full The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title_fullStr The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title_full_unstemmed The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title_short The Prognostic Impact of Combined Tumor-Infiltrating Lymphocytes and Pretreatment Blood Lymphocyte Percentage in Locally Advanced Nasopharyngeal Carcinoma
title_sort prognostic impact of combined tumor-infiltrating lymphocytes and pretreatment blood lymphocyte percentage in locally advanced nasopharyngeal carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804347/
https://www.ncbi.nlm.nih.gov/pubmed/35117992
http://dx.doi.org/10.3389/fonc.2021.788497
work_keys_str_mv AT caizhuochen theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT jiangjiali theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT huanglaiji theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT yuanyawei theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT zhengronghui theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT zhangjiangyu theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT qiuwenze theprognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT caizhuochen prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT jiangjiali prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT huanglaiji prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT yuanyawei prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT zhengronghui prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT zhangjiangyu prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma
AT qiuwenze prognosticimpactofcombinedtumorinfiltratinglymphocytesandpretreatmentbloodlymphocytepercentageinlocallyadvancednasopharyngealcarcinoma